HCSGD entry for MADD

1. General information

Official gene symbolMADD
Entrez ID8567
Gene full nameMAP-kinase activating death domain
Other gene symbolsDENN IG20 RAB3GEP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityIMPbiological_process
GO:0005123Death receptor bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0016021Integral component of membraneIDAcellular_component
GO:0017112Rab guanyl-nucleotide exchange factor activityIDA IMPmolecular_function
GO:0030295Protein kinase activator activityTASmolecular_function
GO:0032313Regulation of Rab GTPase activityIDA IMPbiological_process
GO:0032318Regulation of Ras GTPase activityIDA IMPbiological_process
GO:0032483Regulation of Rab protein signal transductionIDAbiological_process
GO:0042981Regulation of apoptotic processIMPbiological_process
GO:0043087Regulation of GTPase activityIDA IMPbiological_process
GO:0051726Regulation of cell cycleIMPbiological_process
GO:0097194Execution phase of apoptosisIMPbiological_process
GO:1902041Regulation of extrinsic apoptotic signaling pathway via death domain receptorsIMPbiological_process
GO:2001234Negative regulation of apoptotic signaling pathwayIEAbiological_process
GO:2001236Regulation of extrinsic apoptotic signaling pathwayIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07490383720.94726251280.57986585291.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0336380170
GSE13712_SHEARUp0.0246777374
GSE13712_STATICDown-0.0698045900
GSE19018Up0.0551071101
GSE19899_A1Up0.0974963626
GSE19899_A2Up0.1968076337
PubMed_21979375_A1Up1.1287153642
PubMed_21979375_A2Up0.3888041145
GSE35957Down-0.0826681204
GSE36640Up0.0251591918
GSE54402Up0.3154076709
GSE9593Down-0.2396750590
GSE43922Up0.1830562800
GSE24585Up0.4310893137
GSE37065Up0.0963581089
GSE28863_A1Up0.3352850097
GSE28863_A2Up0.6057008860
GSE28863_A3Down-0.2808044379
GSE28863_A4Down-0.1276519048
GSE48662Up0.2302523354

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029280MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.