HCSGD entry for MAP4K3

1. General information

Official gene symbolMAP4K3
Entrez ID8491
Gene full namemitogen-activated protein kinase kinase kinase kinase 3
Other gene symbolsGLK MAPKKKK3 MEKKK 3 MEKKK3 RAB8IPL1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000185Activation of MAPKKK activityIBAbiological_process
GO:0004672Protein kinase activityIEA TASmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEAmolecular_function
GO:0005083Small GTPase regulator activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005737CytoplasmIBAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0008349MAP kinase kinase kinase kinase activityIBAmolecular_function
GO:0009411Response to UVIDAbiological_process
GO:0016301Kinase activityIEAmolecular_function
GO:0016772Transferase activity, transferring phosphorus-containing groupsIEAmolecular_function
GO:0034612Response to tumor necrosis factorIDAbiological_process
GO:0035556Intracellular signal transductionIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.43515012730.21815522590.99999024730.8988917971

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3753500725
GSE13712_SHEARDown-0.0195587719
GSE13712_STATICDown-0.1021648165
GSE19018Down-0.2841235104
GSE19899_A1Down-0.0880618802
GSE19899_A2Up0.3015295540
PubMed_21979375_A1Up0.5752191747
PubMed_21979375_A2Up0.4891227850
GSE35957Up0.0663423220
GSE36640Up0.4543666378
GSE54402Down-0.1427356841
GSE9593Up0.3515792958
GSE43922Down-0.0188761561
GSE24585Down-0.2544554288
GSE37065Up0.3814615478
GSE28863_A1Up0.1257219477
GSE28863_A2Up0.2849964545
GSE28863_A3Down-0.3844670334
GSE28863_A4Down-0.1643590823
GSE48662Down-0.7460444275

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029966MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.