HCSGD entry for MAP4K3

1. General information

Official gene symbolMAP4K3
Entrez ID8491
Gene full namemitogen-activated protein kinase kinase kinase kinase 3
Other gene symbolsGLK MAPKKKK3 MEKKK 3 MEKKK3 RAB8IPL1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000185Activation of MAPKKK activityIBAbiological_process
GO:0004672Protein kinase activityIEA TASmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEAmolecular_function
GO:0005083Small GTPase regulator activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005737CytoplasmIBAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0008349MAP kinase kinase kinase kinase activityIBAmolecular_function
GO:0009411Response to UVIDAbiological_process
GO:0016301Kinase activityIEAmolecular_function
GO:0016772Transferase activity, transferring phosphorus-containing groupsIEAmolecular_function
GO:0034612Response to tumor necrosis factorIDAbiological_process
GO:0035556Intracellular signal transductionIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.43515012730.21815522590.99999024730.8988917971

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3753500725
GSE13712_SHEARDown-0.0195587719
GSE13712_STATICDown-0.1021648165
GSE19018Down-0.2841235104
GSE19899_A1Down-0.0880618802
GSE19899_A2Up0.3015295540
PubMed_21979375_A1Up0.5752191747
PubMed_21979375_A2Up0.4891227850
GSE35957Up0.0663423220
GSE36640Up0.4543666378
GSE54402Down-0.1427356841
GSE9593Up0.3515792958
GSE43922Down-0.0188761561
GSE24585Down-0.2544554288
GSE37065Up0.3814615478
GSE28863_A1Up0.1257219477
GSE28863_A2Up0.2849964545
GSE28863_A3Down-0.3844670334
GSE28863_A4Down-0.1643590823
GSE48662Down-0.7460444275

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029966MicroarrayFunctional MTI (Weak)19088304
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.