HCSGD entry for OGT

1. General information

Official gene symbolOGT
Entrez ID8473
Gene full nameO-linked N-acetylglucosamine (GlcNAc) transferase
Other gene symbolsHRNT1 O-GLCNAC
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000123Histone acetyltransferase complexIDAcellular_component
GO:0005515Protein bindingIPImolecular_function
GO:0005547Phosphatidylinositol-3,4,5-trisphosphate bindingIDAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006110Regulation of glycolysisIDAbiological_process
GO:0006493Protein O-linked glycosylationIDA IMPbiological_process
GO:0006915Apoptotic processIDAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007584Response to nutrientTASbiological_process
GO:0008047Enzyme activator activityIDAmolecular_function
GO:0008375Acetylglucosaminyltransferase activityTASmolecular_function
GO:0016262Protein N-acetylglucosaminyltransferase activityIDAmolecular_function
GO:0030854Positive regulation of granulocyte differentiationIMPbiological_process
GO:0032868Response to insulinIDAbiological_process
GO:0035020Regulation of Rac protein signal transductionIDAbiological_process
GO:0043085Positive regulation of catalytic activityIDAbiological_process
GO:0043981Histone H4-K5 acetylationIDAbiological_process
GO:0043982Histone H4-K8 acetylationIDAbiological_process
GO:0043984Histone H4-K16 acetylationIDAbiological_process
GO:0043995Histone acetyltransferase activity (H4-K5 specific)IDAmolecular_function
GO:0043996Histone acetyltransferase activity (H4-K8 specific)IDAmolecular_function
GO:0045862Positive regulation of proteolysisIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0046626Regulation of insulin receptor signaling pathwayIDAbiological_process
GO:0046972Histone acetyltransferase activity (H4-K16 specific)IDAmolecular_function
GO:0048015Phosphatidylinositol-mediated signalingIDAbiological_process
GO:0050790Regulation of catalytic activityIDAbiological_process
GO:0051571Positive regulation of histone H3-K4 methylationIDAbiological_process
GO:0070688MLL5-L complexIDAcellular_component
GO:0071300Cellular response to retinoic acidIMPbiological_process
GO:0080182Histone H3-K4 trimethylationIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.13845984580.65034071270.74882369721.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2915869707
GSE13712_SHEARUp0.2347547303
GSE13712_STATICDown-0.3719680612
GSE19018Up0.1224539311
GSE19899_A1Up0.1090032424
GSE19899_A2Down-0.0082882152
PubMed_21979375_A1Up0.0211423721
PubMed_21979375_A2Up0.3588946981
GSE35957Up0.2048484756
GSE36640Up0.3246131644
GSE54402Up0.0896956644
GSE9593Down-0.0481402320
GSE43922Up0.2042804955
GSE24585Up0.4255362876
GSE37065Down-0.2017633759
GSE28863_A1Up0.4888520839
GSE28863_A2Up0.1843104596
GSE28863_A3Down-0.6455450578
GSE28863_A4Up0.0062815966
GSE48662Up0.1187019323

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-671-5pMIMAT0003880MIRT039274CLASHFunctional MTI (Weak)23622248
hsa-miR-125a-5pMIMAT0000443MIRT045697CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049427CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050178CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27217568O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence
27217568Here, we show that O-linked N-acetylglucosamine (GlcNAc) transferase (OGT), an enzyme that catalyzes O-GlcNAcylation of serine or threonine residues, interacts with UBN1, modifies HIRA, and promotes nucleosome assembly of H3
27217568Depletion of OGT or expression of the HIRA S231A O-GlcNAcylation-deficient mutant compromises formation of the HIRA-H3
27217568Importantly, OGT depletion or expression of the HIRA S231A mutant delays premature cellular senescence in primary human fibroblasts, whereas overexpression of OGT accelerates senescence
272175683 nucleosome assembly and reveal the mechanism by which OGT functions in cellular senescence
26640786O-GlcNAc status was assessed by Western blot under normal conditions and after modulation with 6-diazo-5-oxo-L-norleucine (DON) to decrease O-GlcNAcylation or O-(2-acetamido-2-deoxy-D-glucopyranosylidene) amino N-phenyl carbamate (PUGNAc) to increase O-GlcNAcylation
26640786DISCUSSION: This study identified changes of the proteome and altered dynamics of O-GlcNAc regulation in senescent mesothelial cells
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