HCSGD entry for OGT
1. General information
Official gene symbol | OGT |
---|---|
Entrez ID | 8473 |
Gene full name | O-linked N-acetylglucosamine (GlcNAc) transferase |
Other gene symbols | HRNT1 O-GLCNAC |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0000123 | Histone acetyltransferase complex | IDA | cellular_component |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005547 | Phosphatidylinositol-3,4,5-trisphosphate binding | IDA | molecular_function |
GO:0005634 | Nucleus | IDA | cellular_component |
GO:0005730 | Nucleolus | IDA | cellular_component |
GO:0005739 | Mitochondrion | IEA | cellular_component |
GO:0005813 | Centrosome | IDA | cellular_component |
GO:0005829 | Cytosol | IDA | cellular_component |
GO:0005886 | Plasma membrane | IDA | cellular_component |
GO:0006110 | Regulation of glycolysis | IDA | biological_process |
GO:0006493 | Protein O-linked glycosylation | IDA IMP | biological_process |
GO:0006915 | Apoptotic process | IDA | biological_process |
GO:0007165 | Signal transduction | TAS | biological_process |
GO:0007584 | Response to nutrient | TAS | biological_process |
GO:0008047 | Enzyme activator activity | IDA | molecular_function |
GO:0008375 | Acetylglucosaminyltransferase activity | TAS | molecular_function |
GO:0016262 | Protein N-acetylglucosaminyltransferase activity | IDA | molecular_function |
GO:0030854 | Positive regulation of granulocyte differentiation | IMP | biological_process |
GO:0032868 | Response to insulin | IDA | biological_process |
GO:0035020 | Regulation of Rac protein signal transduction | IDA | biological_process |
GO:0043085 | Positive regulation of catalytic activity | IDA | biological_process |
GO:0043981 | Histone H4-K5 acetylation | IDA | biological_process |
GO:0043982 | Histone H4-K8 acetylation | IDA | biological_process |
GO:0043984 | Histone H4-K16 acetylation | IDA | biological_process |
GO:0043995 | Histone acetyltransferase activity (H4-K5 specific) | IDA | molecular_function |
GO:0043996 | Histone acetyltransferase activity (H4-K8 specific) | IDA | molecular_function |
GO:0045862 | Positive regulation of proteolysis | IDA | biological_process |
GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA IMP | biological_process |
GO:0046626 | Regulation of insulin receptor signaling pathway | IDA | biological_process |
GO:0046972 | Histone acetyltransferase activity (H4-K16 specific) | IDA | molecular_function |
GO:0048015 | Phosphatidylinositol-mediated signaling | IDA | biological_process |
GO:0050790 | Regulation of catalytic activity | IDA | biological_process |
GO:0051571 | Positive regulation of histone H3-K4 methylation | IDA | biological_process |
GO:0070688 | MLL5-L complex | IDA | cellular_component |
GO:0071300 | Cellular response to retinoic acid | IMP | biological_process |
GO:0080182 | Histone H3-K4 trimethylation | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.1384598458 | 0.6503407127 | 0.7488236972 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Down | -0.2915869707 |
GSE13712_SHEAR | Up | 0.2347547303 |
GSE13712_STATIC | Down | -0.3719680612 |
GSE19018 | Up | 0.1224539311 |
GSE19899_A1 | Up | 0.1090032424 |
GSE19899_A2 | Down | -0.0082882152 |
PubMed_21979375_A1 | Up | 0.0211423721 |
PubMed_21979375_A2 | Up | 0.3588946981 |
GSE35957 | Up | 0.2048484756 |
GSE36640 | Up | 0.3246131644 |
GSE54402 | Up | 0.0896956644 |
GSE9593 | Down | -0.0481402320 |
GSE43922 | Up | 0.2042804955 |
GSE24585 | Up | 0.4255362876 |
GSE37065 | Down | -0.2017633759 |
GSE28863_A1 | Up | 0.4888520839 |
GSE28863_A2 | Up | 0.1843104596 |
GSE28863_A3 | Down | -0.6455450578 |
GSE28863_A4 | Up | 0.0062815966 |
GSE48662 | Up | 0.1187019323 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-miR-671-5p | MIMAT0003880 | MIRT039274 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-125a-5p | MIMAT0000443 | MIRT045697 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-92a-3p | MIMAT0000092 | MIRT049427 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-26a-5p | MIMAT0000082 | MIRT050178 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
27217568 | O-linked N-acetylglucosamine transferase (OGT) interacts with the histone chaperone HIRA complex and regulates nucleosome assembly and cellular senescence |
27217568 | Here, we show that O-linked N-acetylglucosamine (GlcNAc) transferase (OGT), an enzyme that catalyzes O-GlcNAcylation of serine or threonine residues, interacts with UBN1, modifies HIRA, and promotes nucleosome assembly of H3 |
27217568 | Depletion of OGT or expression of the HIRA S231A O-GlcNAcylation-deficient mutant compromises formation of the HIRA-H3 |
27217568 | Importantly, OGT depletion or expression of the HIRA S231A mutant delays premature cellular senescence in primary human fibroblasts, whereas overexpression of OGT accelerates senescence |
27217568 | 3 nucleosome assembly and reveal the mechanism by which OGT functions in cellular senescence |
26640786 | O-GlcNAc status was assessed by Western blot under normal conditions and after modulation with 6-diazo-5-oxo-L-norleucine (DON) to decrease O-GlcNAcylation or O-(2-acetamido-2-deoxy-D-glucopyranosylidene) amino N-phenyl carbamate (PUGNAc) to increase O-GlcNAcylation |
26640786 | DISCUSSION: This study identified changes of the proteome and altered dynamics of O-GlcNAc regulation in senescent mesothelial cells |
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