HCSGD entry for CASQ2

1. General information

Official gene symbolCASQ2
Entrez ID845
Gene full namecalsequestrin 2 (cardiac muscle)
Other gene symbolsPDIB2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002027Regulation of heart rateIMPbiological_process
GO:0005509Calcium ion bindingIDA IEAmolecular_function
GO:0005513Detection of calcium ionTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIMPcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005891Voltage-gated calcium channel complexISScellular_component
GO:0006941Striated muscle contractionTASbiological_process
GO:0010649Regulation of cell communication by electrical couplingIMPbiological_process
GO:0010880Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumISSbiological_process
GO:0010881Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionIMPbiological_process
GO:0014701Junctional sarcoplasmic reticulum membraneTAScellular_component
GO:0016529Sarcoplasmic reticulumISScellular_component
GO:0030018Z discISScellular_component
GO:0033017Sarcoplasmic reticulum membraneTAScellular_component
GO:0033018Sarcoplasmic reticulum lumenICcellular_component
GO:0034220Ion transmembrane transportTASbiological_process
GO:0034704Calcium channel complexTAScellular_component
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0043267Negative regulation of potassium ion transportISSbiological_process
GO:0051208Sequestering of calcium ionIDA IMPbiological_process
GO:0051258Protein polymerizationIDAbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0060048Cardiac muscle contractionIMPbiological_process
GO:0060306Regulation of membrane repolarizationISSbiological_process
GO:0060315Negative regulation of ryanodine-sensitive calcium-release channel activityIDA ISSbiological_process
GO:0071313Cellular response to caffeineIMPbiological_process
GO:0086029Purkinje myocyte to ventricular cardiac muscle cell signalingNASbiological_process
GO:1901017Negative regulation of potassium ion transmembrane transporter activityISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.80801886710.74017047980.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0955216853
GSE13712_SHEARDown-0.0933977274
GSE13712_STATICUp0.0819061479
GSE19018Up0.0138444572
GSE19899_A1Up0.1185265310
GSE19899_A2Up0.1007332924
PubMed_21979375_A1Down-0.2064503355
PubMed_21979375_A2Up0.0307412461
GSE35957Up0.2389377244
GSE36640Down-0.0726687098
GSE54402Down-0.1256807181
GSE9593Down-0.0279529853
GSE43922Up0.0180951815
GSE24585Down-0.0153856927
GSE37065Down-0.0722688113
GSE28863_A1Up0.0547631824
GSE28863_A2Up0.0822720663
GSE28863_A3Up0.0153960967
GSE28863_A4Up0.0940005549
GSE48662Up0.0147249884

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-128-3pMIMAT0000424MIRT021966MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.