HCSGD entry for CASQ2

1. General information

Official gene symbolCASQ2
Entrez ID845
Gene full namecalsequestrin 2 (cardiac muscle)
Other gene symbolsPDIB2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002027Regulation of heart rateIMPbiological_process
GO:0005509Calcium ion bindingIDA IEAmolecular_function
GO:0005513Detection of calcium ionTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIMPcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005891Voltage-gated calcium channel complexISScellular_component
GO:0006941Striated muscle contractionTASbiological_process
GO:0010649Regulation of cell communication by electrical couplingIMPbiological_process
GO:0010880Regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumISSbiological_process
GO:0010881Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionIMPbiological_process
GO:0014701Junctional sarcoplasmic reticulum membraneTAScellular_component
GO:0016529Sarcoplasmic reticulumISScellular_component
GO:0030018Z discISScellular_component
GO:0033017Sarcoplasmic reticulum membraneTAScellular_component
GO:0033018Sarcoplasmic reticulum lumenICcellular_component
GO:0034220Ion transmembrane transportTASbiological_process
GO:0034704Calcium channel complexTAScellular_component
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0043267Negative regulation of potassium ion transportISSbiological_process
GO:0051208Sequestering of calcium ionIDA IMPbiological_process
GO:0051258Protein polymerizationIDAbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0060048Cardiac muscle contractionIMPbiological_process
GO:0060306Regulation of membrane repolarizationISSbiological_process
GO:0060315Negative regulation of ryanodine-sensitive calcium-release channel activityIDA ISSbiological_process
GO:0071313Cellular response to caffeineIMPbiological_process
GO:0086029Purkinje myocyte to ventricular cardiac muscle cell signalingNASbiological_process
GO:1901017Negative regulation of potassium ion transmembrane transporter activityISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.80801886710.74017047980.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0955216853
GSE13712_SHEARDown-0.0933977274
GSE13712_STATICUp0.0819061479
GSE19018Up0.0138444572
GSE19899_A1Up0.1185265310
GSE19899_A2Up0.1007332924
PubMed_21979375_A1Down-0.2064503355
PubMed_21979375_A2Up0.0307412461
GSE35957Up0.2389377244
GSE36640Down-0.0726687098
GSE54402Down-0.1256807181
GSE9593Down-0.0279529853
GSE43922Up0.0180951815
GSE24585Down-0.0153856927
GSE37065Down-0.0722688113
GSE28863_A1Up0.0547631824
GSE28863_A2Up0.0822720663
GSE28863_A3Up0.0153960967
GSE28863_A4Up0.0940005549
GSE48662Up0.0147249884

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-128-3pMIMAT0000424MIRT021966MicroarrayFunctional MTI (Weak)17612493
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.