HCSGD entry for ULK1
1. General information
| Official gene symbol | ULK1 |
|---|---|
| Entrez ID | 8408 |
| Gene full name | unc-51-like kinase 1 (C. elegans) |
| Other gene symbols | ATG1 ATG1A UNC51 Unc51.1 hATG1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000045 | Autophagic vacuole assembly | IEA | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | NAS | cellular_component |
| GO:0005776 | Autophagic vacuole | IDA | cellular_component |
| GO:0005829 | Cytosol | IDA IEA | cellular_component |
| GO:0006468 | Protein phosphorylation | NAS | biological_process |
| GO:0007265 | Ras protein signal transduction | IEA | biological_process |
| GO:0008104 | Protein localization | IMP | biological_process |
| GO:0010506 | Regulation of autophagy | IDA IMP | biological_process |
| GO:0010508 | Positive regulation of autophagy | IEA ISS | biological_process |
| GO:0016239 | Positive regulation of macroautophagy | IMP | biological_process |
| GO:0017137 | Rab GTPase binding | IPI | molecular_function |
| GO:0019901 | Protein kinase binding | IEA | molecular_function |
| GO:0021707 | Cerebellar granule cell differentiation | IEA | biological_process |
| GO:0021933 | Radial glia guided migration of cerebellar granule cell | IEA | biological_process |
| GO:0030659 | Cytoplasmic vesicle membrane | IEA | cellular_component |
| GO:0031102 | Neuron projection regeneration | IEA | biological_process |
| GO:0031175 | Neuron projection development | IMP | biological_process |
| GO:0031623 | Receptor internalization | IEA | biological_process |
| GO:0031669 | Cellular response to nutrient levels | ISS | biological_process |
| GO:0032403 | Protein complex binding | IPI | molecular_function |
| GO:0034045 | Pre-autophagosomal structure membrane | IDA IEA | cellular_component |
| GO:0042594 | Response to starvation | ISS | biological_process |
| GO:0043005 | Neuron projection | IEA | cellular_component |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0046777 | Protein autophosphorylation | IDA IEA | biological_process |
| GO:0048671 | Negative regulation of collateral sprouting | IEA | biological_process |
| GO:0048675 | Axon extension | IEA | biological_process |
| GO:0051386 | Regulation of neurotrophin TRK receptor signaling pathway | IEA | biological_process |
| GO:0070969 | ULK1-ATG13-FIP200 complex | IEA IPI | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0942882641 | 0.8541188671 | 0.6431940415 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0934356304 |
| GSE13712_SHEAR | Down | -0.6089385332 |
| GSE13712_STATIC | Down | -0.0266636105 |
| GSE19018 | Up | 0.4597871446 |
| GSE19899_A1 | Up | 0.0152292070 |
| GSE19899_A2 | Up | 0.0972008946 |
| PubMed_21979375_A1 | Down | -0.1392538950 |
| PubMed_21979375_A2 | Up | 0.0626808268 |
| GSE35957 | Down | -0.5121643131 |
| GSE36640 | Up | 0.4934111634 |
| GSE54402 | Up | 0.1925031684 |
| GSE9593 | Down | -0.1139322875 |
| GSE43922 | Up | 0.1478820543 |
| GSE24585 | Up | 0.1553669406 |
| GSE37065 | Down | -0.0426175387 |
| GSE28863_A1 | Up | 0.3022558884 |
| GSE28863_A2 | Up | 0.1786877437 |
| GSE28863_A3 | Up | 0.2770675059 |
| GSE28863_A4 | Down | -0.0760186289 |
| GSE48662 | Up | 0.6116082570 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017081 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-423-5p | MIMAT0004748 | MIRT038087 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044753 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045246 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051250 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24487029 | We identified kinases such as the mitogen-activated protein kinase and the TGFbetaR protein family, previously implicated in HER2(+) breast cancer, as well as autophagy factor ATG1/ULK1 and the noncanonical IkappaB kinase (IKK), TANK-binding kinase 1 (TBK1), which have not been previously linked to HER2(+) breast cancer |
| 21858089 | In contrast to the lifespan extension effect in lower organisms, it has been reported that overexpression of unc-51-like kinase 3 (ULK3), the mammalian homolog of autophagy-specific gene 1 (ATG1), induces premature senescence in human fibroblasts |
| 21490424 | In addition, we found that Atg13 is gradually rephosphorylated during prolonged nitrogen starvation, and the kinase activity of Atg1 is required for Atg13 rephosphorylation |
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