HCSGD entry for ULK1

1. General information

Official gene symbolULK1
Entrez ID8408
Gene full nameunc-51-like kinase 1 (C. elegans)
Other gene symbolsATG1 ATG1A UNC51 Unc51.1 hATG1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000045Autophagic vacuole assemblyIEAbiological_process
GO:0004674Protein serine/threonine kinase activityIDA IEA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmNAScellular_component
GO:0005776Autophagic vacuoleIDAcellular_component
GO:0005829CytosolIDA IEAcellular_component
GO:0006468Protein phosphorylationNASbiological_process
GO:0007265Ras protein signal transductionIEAbiological_process
GO:0008104Protein localizationIMPbiological_process
GO:0010506Regulation of autophagyIDA IMPbiological_process
GO:0010508Positive regulation of autophagyIEA ISSbiological_process
GO:0016239Positive regulation of macroautophagyIMPbiological_process
GO:0017137Rab GTPase bindingIPImolecular_function
GO:0019901Protein kinase bindingIEAmolecular_function
GO:0021707Cerebellar granule cell differentiationIEAbiological_process
GO:0021933Radial glia guided migration of cerebellar granule cellIEAbiological_process
GO:0030659Cytoplasmic vesicle membraneIEAcellular_component
GO:0031102Neuron projection regenerationIEAbiological_process
GO:0031175Neuron projection developmentIMPbiological_process
GO:0031623Receptor internalizationIEAbiological_process
GO:0031669Cellular response to nutrient levelsISSbiological_process
GO:0032403Protein complex bindingIPImolecular_function
GO:0034045Pre-autophagosomal structure membraneIDA IEAcellular_component
GO:0042594Response to starvationISSbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0046777Protein autophosphorylationIDA IEAbiological_process
GO:0048671Negative regulation of collateral sproutingIEAbiological_process
GO:0048675Axon extensionIEAbiological_process
GO:0051386Regulation of neurotrophin TRK receptor signaling pathwayIEAbiological_process
GO:0070969ULK1-ATG13-FIP200 complexIEA IPIcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.09428826410.85411886710.64319404151.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0934356304
GSE13712_SHEARDown-0.6089385332
GSE13712_STATICDown-0.0266636105
GSE19018Up0.4597871446
GSE19899_A1Up0.0152292070
GSE19899_A2Up0.0972008946
PubMed_21979375_A1Down-0.1392538950
PubMed_21979375_A2Up0.0626808268
GSE35957Down-0.5121643131
GSE36640Up0.4934111634
GSE54402Up0.1925031684
GSE9593Down-0.1139322875
GSE43922Up0.1478820543
GSE24585Up0.1553669406
GSE37065Down-0.0426175387
GSE28863_A1Up0.3022558884
GSE28863_A2Up0.1786877437
GSE28863_A3Up0.2770675059
GSE28863_A4Down-0.0760186289
GSE48662Up0.6116082570

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017081MicroarrayFunctional MTI (Weak)18185580
hsa-miR-423-5pMIMAT0004748MIRT038087CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044753CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT045246CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051250CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24487029We identified kinases such as the mitogen-activated protein kinase and the TGFbetaR protein family, previously implicated in HER2(+) breast cancer, as well as autophagy factor ATG1/ULK1 and the noncanonical IkappaB kinase (IKK), TANK-binding kinase 1 (TBK1), which have not been previously linked to HER2(+) breast cancer
21858089In contrast to the lifespan extension effect in lower organisms, it has been reported that overexpression of unc-51-like kinase 3 (ULK3), the mammalian homolog of autophagy-specific gene 1 (ATG1), induces premature senescence in human fibroblasts
21490424In addition, we found that Atg13 is gradually rephosphorylated during prolonged nitrogen starvation, and the kinase activity of Atg1 is required for Atg13 rephosphorylation
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