HCSGD entry for TAGLN2


1. General information

Official gene symbolTAGLN2
Entrez ID8407
Gene full nametransgelin 2
Other gene symbolsHA1756
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0007517Muscle organ developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.42480695640.02889008020.99999024730.3225510178

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3885422794
GSE13712_SHEARDown-0.0192918639
GSE13712_STATICUp0.2671587659
GSE19018Up0.4313371821
GSE19899_A1Down-1.0705811055
GSE19899_A2Down-0.2798042020
PubMed_21979375_A1Up0.1608286045
PubMed_21979375_A2Down-0.9197056303
GSE35957Down-0.4036625955
GSE36640Down-0.9930667114
GSE54402Up0.4296427579
GSE9593Up0.0480294037
GSE43922Down-0.0510627569
GSE24585Down-1.0031261172
GSE37065Up0.2279062245
GSE28863_A1Up0.0537751094
GSE28863_A2Down-0.0631729676
GSE28863_A3Up0.1915459567
GSE28863_A4Up0.0758752286
GSE48662Up0.2575983558

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT002788Luciferase reporter assayFunctional MTI20144220
hsa-miR-1MIMAT0000416MIRT002788MicroarrayFunctional MTI (Weak)15685193
hsa-miR-1MIMAT0000416MIRT002788pSILAC//ProteomicsFunctional MTI (Weak)18668040
hsa-miR-1MIMAT0000416MIRT002788Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI2130430
hsa-miR-1MIMAT0000416MIRT002788Luciferase reporter assay//Reporter assay;Western blot;qRT-PCRFunctional MTI21745735
hsa-miR-1MIMAT0000416MIRT002788Proteomics;MicroarrayNon-Functional MTI (Weak)18668037
hsa-miR-1MIMAT0000416MIRT002788Western blot;qRT-PCR;MicroarrayFunctional MTI21701775
hsa-miR-133a-3pMIMAT0000427MIRT005604Immunohistochemistry//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI2130430
hsa-miR-133a-3pMIMAT0000427MIRT005604Luciferase reporter assay//Reporter assay;Western blot;qRT-PCRFunctional MTI21745735
hsa-miR-133a-3pMIMAT0000427MIRT005604MicroarrayFunctional MTI (Weak)21396852
hsa-miR-133a-3pMIMAT0000427MIRT005604Western blot;qRT-PCR;MicroarrayFunctional MTI21701775
hsa-miR-93-3pMIMAT0004509MIRT038849CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039889CLASHFunctional MTI (Weak)23622248
hsa-miR-423-3pMIMAT0001340MIRT042618CLASHFunctional MTI (Weak)23622248
hsa-miR-3176MIMAT0015053MIRT052789CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-1MIMAT0000416NAhsa-miR-115685193
hsa-miR-1MIMAT0000416NAhsa-miR-120144220
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26640786RESULTS: Comparison of protein pattern of senescent and young HPMC revealed 29 differentially abundant protein spots, 11 of which were identified to be actin (cytoplasmic 1 and 2), cytokeratin-7, cofilin-2, transgelin-2, Hsp60, Hsc70, proteasome beta-subunits (type-2 and type-3), nucleoside diphosphate kinase A, and cytosolic 5'(3')-deoxyribonucleotidase
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