HCSGD entry for CANX

1. General information

Official gene symbolCANX
Entrez ID821
Gene full namecalnexin
Other gene symbolsCNX IP90 P90
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001948Glycoprotein bindingIEAmolecular_function
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005783Endoplasmic reticulumIDA IEAcellular_component
GO:0005788Endoplasmic reticulum lumenTAScellular_component
GO:0005789Endoplasmic reticulum membraneIDAcellular_component
GO:0005840RibosomeIEAcellular_component
GO:0006457Protein foldingIEA TASbiological_process
GO:0007568AgingIEAbiological_process
GO:0009306Protein secretionTASbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0018279Protein N-linked glycosylation via asparagineTASbiological_process
GO:0019886Antigen processing and presentation of exogenous peptide antigen via MHC class IITASbiological_process
GO:0030424AxonIEAcellular_component
GO:0032839Dendrite cytoplasmIEAcellular_component
GO:0034185Apolipoprotein bindingIEAmolecular_function
GO:0035255Ionotropic glutamate receptor bindingIEAmolecular_function
GO:0042470MelanosomeIEAcellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043197Dendritic spineIEAcellular_component
GO:0043234Protein complexIEAcellular_component
GO:0043687Post-translational protein modificationTASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0048488Synaptic vesicle endocytosisIEA ISSbiological_process
GO:0051082Unfolded protein bindingIEAmolecular_function
GO:0061077Chaperone-mediated protein foldingIEAbiological_process
GO:0071556Integral component of lumenal side of endoplasmic reticulum membraneTAScellular_component
GO:0072583Clathrin-mediated endocytosisIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.12933107020.86172695950.73051057711.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1817565718
GSE13712_SHEARDown-0.2081244421
GSE13712_STATICDown-0.1453650363
GSE19018Up0.3389532216
GSE19899_A1Down-0.2988670504
GSE19899_A2Down-0.1704579629
PubMed_21979375_A1Down-0.3798337450
PubMed_21979375_A2Down-0.2903639885
GSE35957Up0.2813250991
GSE36640Up0.3040685144
GSE54402Down-0.0255001628
GSE9593Up0.2947262483
GSE43922Up0.0338708308
GSE24585Down-0.0757409709
GSE37065Up0.0809376866
GSE28863_A1Up0.4126688449
GSE28863_A2Up1.0427991306
GSE28863_A3Up0.2783762244
GSE28863_A4Down-0.0459980816
GSE48662Up0.4007563692

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

TenecteplaseDB00031 BTD00019 | BIOD00019

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-935MIMAT0004978MIRT036689CLASHFunctional MTI (Weak)23622248
hsa-miR-877-3pMIMAT0004950MIRT037113CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040022CLASHFunctional MTI (Weak)23622248
hsa-miR-342-3pMIMAT0000753MIRT043681CLASHFunctional MTI (Weak)23622248
hsa-miR-30e-5pMIMAT0000692MIRT044143CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044560CLASHFunctional MTI (Weak)23622248
hsa-miR-185-5pMIMAT0000455MIRT045334CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046689CLASHFunctional MTI (Weak)23622248
hsa-miR-196a-5pMIMAT0000226MIRT048231CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-5pMIMAT0000072MIRT050692CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT050869CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25803873Calnexin is essential for survival under nitrogen starvation and stationary phase in Schizosaccharomyces pombe
25803873Previously, we demonstrated that calnexin (Cnx1p), a highly conserved transmembrane chaperone of the endoplasmic reticulum (ER), regulates apoptosis under ER stress or inositol starvation
25803873Ours, and observations in mammalian systems, suggest that the multiple roles of calnexin depend on its sub-cellular localization and on its cleavage
25149687Results show that in replicative senescence and CuSO4-SIPS, immunoglobulin binding protein, calnexin, protein disulfide isomerase, and ER oxireductin-1 levels adjust to restore proteostasis and inositol-requiring enzyme-1 (IRE1)-, activating transcription factor 6 (ATF6)-, and pancreatic ER kinase (PERK)-mediated unfolded protein response are activated
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