HCSGD entry for CANX
1. General information
Official gene symbol | CANX |
---|---|
Entrez ID | 821 |
Gene full name | calnexin |
Other gene symbols | CNX IP90 P90 |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0001948 | Glycoprotein binding | IEA | molecular_function |
GO:0002474 | Antigen processing and presentation of peptide antigen via MHC class I | TAS | biological_process |
GO:0005509 | Calcium ion binding | IEA | molecular_function |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005783 | Endoplasmic reticulum | IDA IEA | cellular_component |
GO:0005788 | Endoplasmic reticulum lumen | TAS | cellular_component |
GO:0005789 | Endoplasmic reticulum membrane | IDA | cellular_component |
GO:0005840 | Ribosome | IEA | cellular_component |
GO:0006457 | Protein folding | IEA TAS | biological_process |
GO:0007568 | Aging | IEA | biological_process |
GO:0009306 | Protein secretion | TAS | biological_process |
GO:0016021 | Integral component of membrane | IEA | cellular_component |
GO:0018279 | Protein N-linked glycosylation via asparagine | TAS | biological_process |
GO:0019886 | Antigen processing and presentation of exogenous peptide antigen via MHC class II | TAS | biological_process |
GO:0030424 | Axon | IEA | cellular_component |
GO:0032839 | Dendrite cytoplasm | IEA | cellular_component |
GO:0034185 | Apolipoprotein binding | IEA | molecular_function |
GO:0035255 | Ionotropic glutamate receptor binding | IEA | molecular_function |
GO:0042470 | Melanosome | IEA | cellular_component |
GO:0043025 | Neuronal cell body | IEA | cellular_component |
GO:0043197 | Dendritic spine | IEA | cellular_component |
GO:0043234 | Protein complex | IEA | cellular_component |
GO:0043687 | Post-translational protein modification | TAS | biological_process |
GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
GO:0048488 | Synaptic vesicle endocytosis | IEA ISS | biological_process |
GO:0051082 | Unfolded protein binding | IEA | molecular_function |
GO:0061077 | Chaperone-mediated protein folding | IEA | biological_process |
GO:0071556 | Integral component of lumenal side of endoplasmic reticulum membrane | TAS | cellular_component |
GO:0072583 | Clathrin-mediated endocytosis | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.1293310702 | 0.8617269595 | 0.7305105771 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Up | 0.1817565718 |
GSE13712_SHEAR | Down | -0.2081244421 |
GSE13712_STATIC | Down | -0.1453650363 |
GSE19018 | Up | 0.3389532216 |
GSE19899_A1 | Down | -0.2988670504 |
GSE19899_A2 | Down | -0.1704579629 |
PubMed_21979375_A1 | Down | -0.3798337450 |
PubMed_21979375_A2 | Down | -0.2903639885 |
GSE35957 | Up | 0.2813250991 |
GSE36640 | Up | 0.3040685144 |
GSE54402 | Down | -0.0255001628 |
GSE9593 | Up | 0.2947262483 |
GSE43922 | Up | 0.0338708308 |
GSE24585 | Down | -0.0757409709 |
GSE37065 | Up | 0.0809376866 |
GSE28863_A1 | Up | 0.4126688449 |
GSE28863_A2 | Up | 1.0427991306 |
GSE28863_A3 | Up | 0.2783762244 |
GSE28863_A4 | Down | -0.0459980816 |
GSE48662 | Up | 0.4007563692 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
---|---|---|
Tenecteplase | DB00031 | BTD00019 | BIOD00019 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
---|---|---|---|---|---|
hsa-miR-935 | MIMAT0004978 | MIRT036689 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-877-3p | MIMAT0004950 | MIRT037113 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-615-3p | MIMAT0003283 | MIRT040022 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-342-3p | MIMAT0000753 | MIRT043681 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-30e-5p | MIMAT0000692 | MIRT044143 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-320a | MIMAT0000510 | MIRT044560 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-185-5p | MIMAT0000455 | MIRT045334 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-222-3p | MIMAT0000279 | MIRT046689 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-196a-5p | MIMAT0000226 | MIRT048231 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-18a-5p | MIMAT0000072 | MIRT050692 | CLASH | Functional MTI (Weak) | 23622248 |
hsa-miR-17-5p | MIMAT0000070 | MIRT050869 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
25803873 | Calnexin is essential for survival under nitrogen starvation and stationary phase in Schizosaccharomyces pombe |
25803873 | Previously, we demonstrated that calnexin (Cnx1p), a highly conserved transmembrane chaperone of the endoplasmic reticulum (ER), regulates apoptosis under ER stress or inositol starvation |
25803873 | Ours, and observations in mammalian systems, suggest that the multiple roles of calnexin depend on its sub-cellular localization and on its cleavage |
25149687 | Results show that in replicative senescence and CuSO4-SIPS, immunoglobulin binding protein, calnexin, protein disulfide isomerase, and ER oxireductin-1 levels adjust to restore proteostasis and inositol-requiring enzyme-1 (IRE1)-, activating transcription factor 6 (ATF6)-, and pancreatic ER kinase (PERK)-mediated unfolded protein response are activated |
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