HCSGD entry for GDF5

1. General information

Official gene symbolGDF5
Entrez ID8200
Gene full namegrowth differentiation factor 5
Other gene symbolsBDA1C BMP14 CDMP1 LAP4 OS5 SYNS2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002062Chondrocyte differentiationIEAbiological_process
GO:0005125Cytokine activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030326Embryonic limb morphogenesisIEAbiological_process
GO:0032332Positive regulation of chondrocyte differentiationIEAbiological_process
GO:0035136Forelimb morphogenesisIEAbiological_process
GO:0035137Hindlimb morphogenesisIEAbiological_process
GO:0040007GrowthIEAbiological_process
GO:0040014Regulation of multicellular organism growthIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIDAbiological_process
GO:2001054Negative regulation of mesenchymal cell apoptotic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.22549477980.01286268760.90683699010.2238464026

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1537448129
GSE13712_SHEARUp0.1878489075
GSE13712_STATICDown-0.1496481901
GSE19018Up0.1903431856
GSE19899_A1Down-0.0451919868
GSE19899_A2Down-0.6224536527
PubMed_21979375_A1Down-2.1528707313
PubMed_21979375_A2Down-1.0923711637
GSE35957Up0.3604431421
GSE36640Down-1.2200431250
GSE54402Down-0.8149061734
GSE9593Up1.9536250696
GSE43922Down-1.3752379379
GSE24585Up0.0561658864
GSE37065Down-0.6562807567
GSE28863_A1Down-0.0519697992
GSE28863_A2Up0.9608859893
GSE28863_A3Up0.4077809948
GSE28863_A4Up0.0288946590
GSE48662Down-0.4619644153

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Isopropyl AlcoholDB02325 EXPT01912 | DB04402

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017506MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.