HCSGD entry for GDF5

1. General information

Official gene symbolGDF5
Entrez ID8200
Gene full namegrowth differentiation factor 5
Other gene symbolsBDA1C BMP14 CDMP1 LAP4 OS5 SYNS2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002062Chondrocyte differentiationIEAbiological_process
GO:0005125Cytokine activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030326Embryonic limb morphogenesisIEAbiological_process
GO:0032332Positive regulation of chondrocyte differentiationIEAbiological_process
GO:0035136Forelimb morphogenesisIEAbiological_process
GO:0035137Hindlimb morphogenesisIEAbiological_process
GO:0040007GrowthIEAbiological_process
GO:0040014Regulation of multicellular organism growthIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0050680Negative regulation of epithelial cell proliferationIDAbiological_process
GO:2001054Negative regulation of mesenchymal cell apoptotic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.22549477980.01286268760.90683699010.2238464026

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1537448129
GSE13712_SHEARUp0.1878489075
GSE13712_STATICDown-0.1496481901
GSE19018Up0.1903431856
GSE19899_A1Down-0.0451919868
GSE19899_A2Down-0.6224536527
PubMed_21979375_A1Down-2.1528707313
PubMed_21979375_A2Down-1.0923711637
GSE35957Up0.3604431421
GSE36640Down-1.2200431250
GSE54402Down-0.8149061734
GSE9593Up1.9536250696
GSE43922Down-1.3752379379
GSE24585Up0.0561658864
GSE37065Down-0.6562807567
GSE28863_A1Down-0.0519697992
GSE28863_A2Up0.9608859893
GSE28863_A3Up0.4077809948
GSE28863_A4Up0.0288946590
GSE48662Down-0.4619644153

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Isopropyl AlcoholDB02325 EXPT01912 | DB04402

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017506MicroarrayFunctional MTI (Weak)18185580
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.