HCSGD entry for CALU
1. General information
| Official gene symbol | CALU |
|---|---|
| Entrez ID | 813 |
| Gene full name | calumenin |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0005509 | Calcium ion binding | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | TAS | cellular_component |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008150 | Biological_process | ND | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0033018 | Sarcoplasmic reticulum lumen | IEA | cellular_component |
| GO:0042470 | Melanosome | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6281407659 | 0.0369897838 | 0.9999902473 | 0.3626113222 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5953018730 |
| GSE13712_SHEAR | Down | -0.1507020676 |
| GSE13712_STATIC | Down | -0.1648348195 |
| GSE19018 | Up | 0.5592291845 |
| GSE19899_A1 | Down | -0.8591762083 |
| GSE19899_A2 | Down | -0.6369629462 |
| PubMed_21979375_A1 | Down | -0.7916644232 |
| PubMed_21979375_A2 | Down | -1.1004665085 |
| GSE35957 | Up | 0.3186526232 |
| GSE36640 | Up | 0.1156762704 |
| GSE54402 | Down | -0.3545216942 |
| GSE9593 | Up | 0.4963073015 |
| GSE43922 | Up | 0.0055799940 |
| GSE24585 | Up | 0.0990130871 |
| GSE37065 | Down | -0.1172323820 |
| GSE28863_A1 | Down | -0.0947485201 |
| GSE28863_A2 | Up | 0.6261974141 |
| GSE28863_A3 | Down | -0.0802405429 |
| GSE28863_A4 | Down | -0.3905922814 |
| GSE48662 | Down | -0.0114542690 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019978 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT021030 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-132-3p | MIMAT0000426 | MIRT021863 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023190 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-122-5p | MIMAT0000421 | MIRT023336 | Proteomics | Functional MTI (Weak) | 21750653 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025946 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027157 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT032058 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-365a-3p | MIMAT0000710 | MIRT044024 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044559 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT048381 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26161649 | Fibulin-1C, C1 Esterase Inhibitor and Glucose Regulated Protein 75 Interact with the CREC Proteins, Calumenin and Reticulocalbin |
| 26161649 | Affinity purification, immunoprecipitation, gel electrophoresis and mass spectrometry were used to identify fibulin-1C, C1 esterase inhibitor and glucose regulated protein 75, grp75, as binding partners of the CREC proteins, calumenin and reticulocalbin |
| 26161649 | Fibulin-1C interacts with calumenin and reticulocalbin with an estimated dissociation constant around 50-60 nM |
| 26161649 | C1 esterase inhibitor interacted with both proteins with an estimated dissociation constant at 1 muM for reticulocalbin and 150 nM for calumenin |
| 26161649 | The interaction, at least for calumenin, was dependent upon the presence of Ca2+ with strong interaction at 3 |
| 26161649 | Grp75 binds with an affinity of approximately 3-7 nM with reticulocalbin as well as with calumenin |
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