HCSGD entry for CALU


1. General information

Official gene symbolCALU
Entrez ID813
Gene full namecalumenin
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002576Platelet degranulationTASbiological_process
GO:0005509Calcium ion bindingIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005794Golgi apparatusTAScellular_component
GO:0007596Blood coagulationTASbiological_process
GO:0008150Biological_processNDbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0033018Sarcoplasmic reticulum lumenIEAcellular_component
GO:0042470MelanosomeIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.62814076590.03698978380.99999024730.3626113222

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5953018730
GSE13712_SHEARDown-0.1507020676
GSE13712_STATICDown-0.1648348195
GSE19018Up0.5592291845
GSE19899_A1Down-0.8591762083
GSE19899_A2Down-0.6369629462
PubMed_21979375_A1Down-0.7916644232
PubMed_21979375_A2Down-1.1004665085
GSE35957Up0.3186526232
GSE36640Up0.1156762704
GSE54402Down-0.3545216942
GSE9593Up0.4963073015
GSE43922Up0.0055799940
GSE24585Up0.0990130871
GSE37065Down-0.1172323820
GSE28863_A1Down-0.0947485201
GSE28863_A2Up0.6261974141
GSE28863_A3Down-0.0802405429
GSE28863_A4Down-0.3905922814
GSE48662Down-0.0114542690

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT019978MicroarrayFunctional MTI (Weak)20215506
hsa-miR-155-5pMIMAT0000646MIRT021030ProteomicsFunctional MTI (Weak)18668040
hsa-miR-132-3pMIMAT0000426MIRT021863MicroarrayFunctional MTI (Weak)17612493
hsa-miR-124-3pMIMAT0000422MIRT023190MicroarrayFunctional MTI (Weak)18668037
hsa-miR-122-5pMIMAT0000421MIRT023336ProteomicsFunctional MTI (Weak)21750653
hsa-miR-7-5pMIMAT0000252MIRT025946MicroarrayFunctional MTI (Weak)17612493
hsa-miR-103a-3pMIMAT0000101MIRT027157SequencingFunctional MTI (Weak)20371350
hsa-miR-16-5pMIMAT0000069MIRT032058SequencingFunctional MTI (Weak)20371350
hsa-miR-365a-3pMIMAT0000710MIRT044024CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044559CLASHFunctional MTI (Weak)23622248
hsa-miR-29b-3pMIMAT0000100MIRT048381CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26161649Fibulin-1C, C1 Esterase Inhibitor and Glucose Regulated Protein 75 Interact with the CREC Proteins, Calumenin and Reticulocalbin
26161649Affinity purification, immunoprecipitation, gel electrophoresis and mass spectrometry were used to identify fibulin-1C, C1 esterase inhibitor and glucose regulated protein 75, grp75, as binding partners of the CREC proteins, calumenin and reticulocalbin
26161649Fibulin-1C interacts with calumenin and reticulocalbin with an estimated dissociation constant around 50-60 nM
26161649C1 esterase inhibitor interacted with both proteins with an estimated dissociation constant at 1 muM for reticulocalbin and 150 nM for calumenin
26161649The interaction, at least for calumenin, was dependent upon the presence of Ca2+ with strong interaction at 3
26161649Grp75 binds with an affinity of approximately 3-7 nM with reticulocalbin as well as with calumenin
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