HCSGD entry for CALM3

1. General information

Official gene symbolCALM3
Entrez ID808
Gene full namecalmodulin 3 (phosphorylase kinase, delta)
Other gene symbolsPHKD PHKD3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001975Response to amphetamineIEAbiological_process
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0007190Activation of adenylate cyclase activityIEAbiological_process
GO:0008179Adenylate cyclase bindingIEAmolecular_function
GO:0016301Kinase activityIEAmolecular_function
GO:0019722Calcium-mediated signalingIEAbiological_process
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030235Nitric-oxide synthase regulator activityIEAmolecular_function
GO:0030426Growth coneIEAcellular_component
GO:0031800Type 3 metabotropic glutamate receptor bindingIEAmolecular_function
GO:0043548Phosphatidylinositol 3-kinase bindingIEAmolecular_function
GO:0044325Ion channel bindingIEAmolecular_function
GO:0047485Protein N-terminus bindingIEAmolecular_function
GO:0048306Calcium-dependent protein bindingIEAmolecular_function
GO:0050998Nitric-oxide synthase bindingIEAmolecular_function
GO:0051000Positive regulation of nitric-oxide synthase activityIEAbiological_process
GO:0051412Response to corticosteroneIEAbiological_process
GO:0060314Regulation of ryanodine-sensitive calcium-release channel activityIEAbiological_process
GO:1901841Regulation of high voltage-gated calcium channel activityIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.93671707760.10472964550.99999024730.6208158001

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3382773465
GSE13712_SHEARDown-0.2514400749
GSE13712_STATICUp0.0070269237
GSE19018Up0.1106706243
GSE19899_A1Up0.2262076205
GSE19899_A2Down-0.1989469349
PubMed_21979375_A1Down-0.6575350421
PubMed_21979375_A2Down-0.4028213466
GSE35957Up0.0305388076
GSE36640Down-0.5409269230
GSE54402Down-0.1080200463
GSE9593Down-0.2140194741
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Down-0.0982331786
GSE28863_A2Down-0.1142764718
GSE28863_A3Down-0.2435989630
GSE28863_A4Up0.1814764099
GSE48662Up0.0983650673

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NicardipineDB00622 APRD00088
IsofluraneDB00753 APRD00212
LoperamideDB00836 APRD00275
PhenoxybenzamineDB00925 APRD00651
MelatoninDB01065 APRD00742 | DB08189
PimozideDB01100 APRD00218
NifedipineDB01115 APRD00590
BepridilDB01244 APRD00727
CalciumDB01373 -
AprindineDB01429 -
3''-(Beta-Chloroethyl)-2'',4''-Dioxo-3, 5''-Spiro-Oxazolidino-4-Deacetoxy-VinblastineDB02868 EXPT01963
2-Methyl-2-PropanolDB03900 EXPT03021
N-TrimethyllysineDB03977 EXPT02087
N-(6-Aminohexyl)-5-Chloro-1-NaphthalenesulfonamideDB04513 EXPT03246
FlunarizineDB04841 -
(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDEDB08039 -
MYRISTIC ACIDDB08231 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT004467ProteomicsFunctional MTI (Weak)18668040
hsa-miR-7-5pMIMAT0000252MIRT025949MicroarrayFunctional MTI (Weak)19073608
hsa-miR-320aMIMAT0000510MIRT044685CLASHFunctional MTI (Weak)23622248
hsa-miR-27b-3pMIMAT0000419MIRT046170CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.