HCSGD entry for CUBN

1. General information

Official gene symbolCUBN
Entrez ID8029
Gene full namecubilin (intrinsic factor-cobalamin receptor)
Other gene symbolsIFCR MGA1 gp280
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001894Tissue homeostasisNASbiological_process
GO:0004872Receptor activityTASmolecular_function
GO:0005215Transporter activityTASmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005765Lysosomal membraneIEAcellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005905Coated pitIEAcellular_component
GO:0006766Vitamin metabolic processTASbiological_process
GO:0006767Water-soluble vitamin metabolic processTASbiological_process
GO:0006898Receptor-mediated endocytosisNASbiological_process
GO:0008202Steroid metabolic processTASbiological_process
GO:0008203Cholesterol metabolic processIEAbiological_process
GO:0009235Cobalamin metabolic processTASbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0015889Cobalamin transportTASbiological_process
GO:0016020MembraneTAScellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0030139Endocytic vesicleIEAcellular_component
GO:0031232Extrinsic component of external side of plasma membraneNAScellular_component
GO:0031419Cobalamin bindingIEAmolecular_function
GO:0031526Brush border membraneNAScellular_component
GO:0042157Lipoprotein metabolic processTASbiological_process
GO:0042359Vitamin D metabolic processTASbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0042953Lipoprotein transportIEAbiological_process
GO:0043202Lysosomal lumenTAScellular_component
GO:0044281Small molecule metabolic processTASbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04790190340.97610063450.48381657711.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4486771146
GSE13712_SHEARUp0.1409985594
GSE13712_STATICUp0.3687881216
GSE19018Up0.0723657926
GSE19899_A1Up0.1223760974
GSE19899_A2Up0.5569407426
PubMed_21979375_A1Up0.2473063958
PubMed_21979375_A2Up0.5549694199
GSE35957Up0.1727768723
GSE36640Up0.1208868751
GSE54402Up0.3011025485
GSE9593Down-0.0765663893
GSE43922Up0.6417980674
GSE24585Up0.1702762517
GSE37065Up0.0344235781
GSE28863_A1Down-0.0586251756
GSE28863_A2Down-0.0630332286
GSE28863_A3Up0.0200430612
GSE28863_A4Down-0.0456260621
GSE48662Up0.0777327170

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

HydroxocobalaminDB00200 APRD01022

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.