HCSGD entry for CUBN

1. General information

Official gene symbolCUBN
Entrez ID8029
Gene full namecubilin (intrinsic factor-cobalamin receptor)
Other gene symbolsIFCR MGA1 gp280
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001894Tissue homeostasisNASbiological_process
GO:0004872Receptor activityTASmolecular_function
GO:0005215Transporter activityTASmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005765Lysosomal membraneIEAcellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005905Coated pitIEAcellular_component
GO:0006766Vitamin metabolic processTASbiological_process
GO:0006767Water-soluble vitamin metabolic processTASbiological_process
GO:0006898Receptor-mediated endocytosisNASbiological_process
GO:0008202Steroid metabolic processTASbiological_process
GO:0008203Cholesterol metabolic processIEAbiological_process
GO:0009235Cobalamin metabolic processTASbiological_process
GO:0010008Endosome membraneTAScellular_component
GO:0015889Cobalamin transportTASbiological_process
GO:0016020MembraneTAScellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0030139Endocytic vesicleIEAcellular_component
GO:0031232Extrinsic component of external side of plasma membraneNAScellular_component
GO:0031419Cobalamin bindingIEAmolecular_function
GO:0031526Brush border membraneNAScellular_component
GO:0042157Lipoprotein metabolic processTASbiological_process
GO:0042359Vitamin D metabolic processTASbiological_process
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0042953Lipoprotein transportIEAbiological_process
GO:0043202Lysosomal lumenTAScellular_component
GO:0044281Small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04790190340.97610063450.48381657711.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4486771146
GSE13712_SHEARUp0.1409985594
GSE13712_STATICUp0.3687881216
GSE19018Up0.0723657926
GSE19899_A1Up0.1223760974
GSE19899_A2Up0.5569407426
PubMed_21979375_A1Up0.2473063958
PubMed_21979375_A2Up0.5549694199
GSE35957Up0.1727768723
GSE36640Up0.1208868751
GSE54402Up0.3011025485
GSE9593Down-0.0765663893
GSE43922Up0.6417980674
GSE24585Up0.1702762517
GSE37065Up0.0344235781
GSE28863_A1Down-0.0586251756
GSE28863_A2Down-0.0630332286
GSE28863_A3Up0.0200430612
GSE28863_A4Down-0.0456260621
GSE48662Up0.0777327170

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

HydroxocobalaminDB00200 APRD01022

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.