HCSGD entry for PLA2G7

1. General information

Official gene symbolPLA2G7
Entrez ID7941
Gene full namephospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Other gene symbolsLDL-PLA2 LP-PLA2 PAFAD PAFAH
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:00038471-alkyl-2-acetylglycerophosphocholine esterase activityIEAmolecular_function
GO:0005543Phospholipid bindingIDAmolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0016042Lipid catabolic processIEAbiological_process
GO:0034362Low-density lipoprotein particleIDAcellular_component
GO:0034374Low-density lipoprotein particle remodelingIDAbiological_process
GO:0034440Lipid oxidationIDAbiological_process
GO:0034441Plasma lipoprotein particle oxidationIDAbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0047499Calcium-independent phospholipase A2 activityIDAmolecular_function
GO:0050729Positive regulation of inflammatory responseTASbiological_process
GO:0090026Positive regulation of monocyte chemotaxisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.45174991450.88358713570.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0792172742
GSE13712_SHEARDown-0.0419111009
GSE13712_STATICUp0.1178147615
GSE19018Up0.1595977115
GSE19899_A1Up0.0740390578
GSE19899_A2Up0.1546962435
PubMed_21979375_A1Up0.0116904431
PubMed_21979375_A2Up0.2368822925
GSE35957Up0.0248972085
GSE36640Down-0.1096106332
GSE54402Down-0.0475980409
GSE9593Down-0.0951135085
GSE43922Down-0.1243680613
GSE24585Up0.3669857441
GSE37065Up0.1080980737
GSE28863_A1Down-0.0658077771
GSE28863_A2Up0.0617068676
GSE28863_A3Up0.0727485249
GSE28863_A4Up0.0202197817
GSE48662Down-0.0078378025

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

659032DB05256 -
(1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATEDB07821 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017286MicroarrayFunctional MTI (Weak)18185580
hsa-miR-124-3pMIMAT0000422MIRT022422MicroarrayFunctional MTI (Weak)18668037
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.