HCSGD entry for TUBA1A
1. General information
| Official gene symbol | TUBA1A |
|---|---|
| Entrez ID | 7846 |
| Gene full name | tubulin, alpha 1a |
| Other gene symbols | B-ALPHA-1 LIS3 TUBA3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | biological_process |
| GO:0000226 | Microtubule cytoskeleton organization | IEA | biological_process |
| GO:0000278 | Mitotic cell cycle | TAS | biological_process |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0005198 | Structural molecule activity | TAS | molecular_function |
| GO:0005200 | Structural constituent of cytoskeleton | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005874 | Microtubule | IDA IEA TAS | cellular_component |
| GO:0005881 | Cytoplasmic microtubule | IEA | cellular_component |
| GO:0006457 | Protein folding | TAS | biological_process |
| GO:0007017 | Microtubule-based process | IEA TAS | biological_process |
| GO:0015630 | Microtubule cytoskeleton | IDA | cellular_component |
| GO:0019904 | Protein domain specific binding | IEA | molecular_function |
| GO:0030705 | Cytoskeleton-dependent intracellular transport | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0051084 | 'de novo' posttranslational protein folding | TAS | biological_process |
| GO:0051258 | Protein polymerization | IEA | biological_process |
| GO:0051301 | Cell division | TAS | biological_process |
| GO:0071353 | Cellular response to interleukin-4 | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9781005091 | 0.0450318225 | 0.9999902473 | 0.3991464046 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0197939992 |
| GSE13712_SHEAR | Up | 0.1350365242 |
| GSE13712_STATIC | Down | -0.0349377547 |
| GSE19018 | Up | 0.2214562978 |
| GSE19899_A1 | Down | -0.0593153954 |
| GSE19899_A2 | Down | -0.0601315320 |
| PubMed_21979375_A1 | Down | -0.7956016007 |
| PubMed_21979375_A2 | Down | -0.2747013511 |
| GSE35957 | Down | -0.4686834919 |
| GSE36640 | Up | 0.0327981086 |
| GSE54402 | Down | -0.0888813496 |
| GSE9593 | Down | -0.3719462333 |
| GSE43922 | Down | -0.4333713138 |
| GSE24585 | Down | -0.0923578917 |
| GSE37065 | Down | -0.5697538288 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -1.0218898427 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Vinblastine | DB00570 | APRD00708 |
| Mebendazole | DB00643 | APRD01086 |
| Epothilone D | DB01873 | EXPT01350 |
| Epothilone B | DB03010 | EXPT01349 |
| CYT997 | DB05147 | - |
| 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE | DB07574 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-30a-3p | MIMAT0000088 | MIRT001765 | qRT-PCR | Functional MTI (Weak) | 16239240 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022850 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037050 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037731 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040369 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-5p | MIMAT0000761 | MIRT043046 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047713 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051216 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
