HCSGD entry for TUBA1A

1. General information

Official gene symbolTUBA1A
Entrez ID7846
Gene full nametubulin, alpha 1a
Other gene symbolsB-ALPHA-1 LIS3 TUBA3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000226Microtubule cytoskeleton organizationIEAbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0003924GTPase activityIEAmolecular_function
GO:0005198Structural molecule activityTASmolecular_function
GO:0005200Structural constituent of cytoskeletonIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005874MicrotubuleIDA IEA TAScellular_component
GO:0005881Cytoplasmic microtubuleIEAcellular_component
GO:0006457Protein foldingTASbiological_process
GO:0007017Microtubule-based processIEA TASbiological_process
GO:0015630Microtubule cytoskeletonIDAcellular_component
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0030705Cytoskeleton-dependent intracellular transportTASbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0051084'de novo' posttranslational protein foldingTASbiological_process
GO:0051258Protein polymerizationIEAbiological_process
GO:0051301Cell divisionTASbiological_process
GO:0071353Cellular response to interleukin-4IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97810050910.04503182250.99999024730.3991464046

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0197939992
GSE13712_SHEARUp0.1350365242
GSE13712_STATICDown-0.0349377547
GSE19018Up0.2214562978
GSE19899_A1Down-0.0593153954
GSE19899_A2Down-0.0601315320
PubMed_21979375_A1Down-0.7956016007
PubMed_21979375_A2Down-0.2747013511
GSE35957Down-0.4686834919
GSE36640Up0.0327981086
GSE54402Down-0.0888813496
GSE9593Down-0.3719462333
GSE43922Down-0.4333713138
GSE24585Down-0.0923578917
GSE37065Down-0.5697538288
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Down-1.0218898427

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

VinblastineDB00570 APRD00708
MebendazoleDB00643 APRD01086
Epothilone DDB01873 EXPT01350
Epothilone BDB03010 EXPT01349
CYT997DB05147 -
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDEDB07574 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30a-3pMIMAT0000088MIRT001765qRT-PCRFunctional MTI (Weak)16239240
hsa-miR-124-3pMIMAT0000422MIRT022850MicroarrayFunctional MTI (Weak)18668037
hsa-miR-877-3pMIMAT0004950MIRT037050CLASHFunctional MTI (Weak)23622248
hsa-miR-744-5pMIMAT0004945MIRT037731CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040369CLASHFunctional MTI (Weak)23622248
hsa-miR-324-5pMIMAT0000761MIRT043046CLASHFunctional MTI (Weak)23622248
hsa-miR-10a-5pMIMAT0000253MIRT047713CLASHFunctional MTI (Weak)23622248
hsa-miR-16-5pMIMAT0000069MIRT051216CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.