HCSGD entry for CACNA1D

1. General information

Official gene symbolCACNA1D
Entrez ID776
Gene full namecalcium channel, voltage-dependent, L type, alpha 1D subunit
Other gene symbolsCACH3 CACN4 CACNL1A2 CCHL1A2 Cav1.3 SANDD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005245Voltage-gated calcium channel activityIDA IEAmolecular_function
GO:0005886Plasma membraneISS TAScellular_component
GO:0005891Voltage-gated calcium channel complexIDA IEAcellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006816Calcium ion transportIDAbiological_process
GO:0007188Adenylate cyclase-modulating G-protein coupled receptor signaling pathwayISSbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007605Sensory perception of soundIMPbiological_process
GO:0008331High voltage-gated calcium channel activityIDAmolecular_function
GO:0030018Z discISScellular_component
GO:0030506Ankyrin bindingISSmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0051393Alpha-actinin bindingIPImolecular_function
GO:0051928Positive regulation of calcium ion transportIDAbiological_process
GO:0060372Regulation of atrial cardiac muscle cell membrane repolarizationISSbiological_process
GO:0070509Calcium ion importIDAbiological_process
GO:0070588Calcium ion transmembrane transportISSbiological_process
GO:0086007Voltage-gated calcium channel activity involved in cardiac muscle cell action potentialICmolecular_function
GO:0086012Membrane depolarization during cardiac muscle cell action potentialICbiological_process
GO:0086052Membrane repolarization during SA node cell action potentialIMPbiological_process
GO:0086059Voltage-gated calcium channel activity involved SA node cell action potentialIMPmolecular_function
GO:0086091Regulation of heart rate by cardiac conductionIMPbiological_process
GO:1901016Regulation of potassium ion transmembrane transporter activityISSbiological_process
GO:1901379Regulation of potassium ion transmembrane transportISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.73925461800.87381569470.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0355353297
GSE13712_SHEARDown-0.0813717631
GSE13712_STATICDown-0.0227954361
GSE19018Up0.0689868718
GSE19899_A1Up0.0817020932
GSE19899_A2Down-0.1374095810
PubMed_21979375_A1Down-0.1204715946
PubMed_21979375_A2Down-0.0901322551
GSE35957Up0.0643236278
GSE36640Down-0.0734421363
GSE54402Up0.0423143235
GSE9593Up0.0178911393
GSE43922Up0.0114439738
GSE24585Up0.4234740039
GSE37065Down-0.0714779699
GSE28863_A1Down-0.0169361121
GSE28863_A2Up0.1472516048
GSE28863_A3Up0.1614320447
GSE28863_A4Up0.1047654957
GSE48662Up0.0848383827

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

IsradipineDB00270 APRD00298
NisoldipineDB00401 APRD00635
CinnarizineDB00568 APRD00332
NicardipineDB00622 APRD00088
VerapamilDB00661 APRD00335
NitrendipineDB01054 APRD00421
NifedipineDB01115 APRD00590
MibefradilDB01388 -
DronedaroneDB04855 -
ClevidipineDB04920 -
NilvadipineDB06712 -
SpironolactoneDB00421 APRD01234

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.