HCSGD entry for CACNA1D

1. General information

Official gene symbolCACNA1D
Entrez ID776
Gene full namecalcium channel, voltage-dependent, L type, alpha 1D subunit
Other gene symbolsCACH3 CACN4 CACNL1A2 CCHL1A2 Cav1.3 SANDD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005245Voltage-gated calcium channel activityIDA IEAmolecular_function
GO:0005886Plasma membraneISS TAScellular_component
GO:0005891Voltage-gated calcium channel complexIDA IEAcellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0006816Calcium ion transportIDAbiological_process
GO:0007188Adenylate cyclase-modulating G-protein coupled receptor signaling pathwayISSbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007605Sensory perception of soundIMPbiological_process
GO:0008331High voltage-gated calcium channel activityIDAmolecular_function
GO:0030018Z discISScellular_component
GO:0030506Ankyrin bindingISSmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0051393Alpha-actinin bindingIPImolecular_function
GO:0051928Positive regulation of calcium ion transportIDAbiological_process
GO:0060372Regulation of atrial cardiac muscle cell membrane repolarizationISSbiological_process
GO:0070509Calcium ion importIDAbiological_process
GO:0070588Calcium ion transmembrane transportISSbiological_process
GO:0086007Voltage-gated calcium channel activity involved in cardiac muscle cell action potentialICmolecular_function
GO:0086012Membrane depolarization during cardiac muscle cell action potentialICbiological_process
GO:0086052Membrane repolarization during SA node cell action potentialIMPbiological_process
GO:0086059Voltage-gated calcium channel activity involved SA node cell action potentialIMPmolecular_function
GO:0086091Regulation of heart rate by cardiac conductionIMPbiological_process
GO:1901016Regulation of potassium ion transmembrane transporter activityISSbiological_process
GO:1901379Regulation of potassium ion transmembrane transportISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.73925461800.87381569470.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0355353297
GSE13712_SHEARDown-0.0813717631
GSE13712_STATICDown-0.0227954361
GSE19018Up0.0689868718
GSE19899_A1Up0.0817020932
GSE19899_A2Down-0.1374095810
PubMed_21979375_A1Down-0.1204715946
PubMed_21979375_A2Down-0.0901322551
GSE35957Up0.0643236278
GSE36640Down-0.0734421363
GSE54402Up0.0423143235
GSE9593Up0.0178911393
GSE43922Up0.0114439738
GSE24585Up0.4234740039
GSE37065Down-0.0714779699
GSE28863_A1Down-0.0169361121
GSE28863_A2Up0.1472516048
GSE28863_A3Up0.1614320447
GSE28863_A4Up0.1047654957
GSE48662Up0.0848383827

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

IsradipineDB00270 APRD00298
NisoldipineDB00401 APRD00635
CinnarizineDB00568 APRD00332
NicardipineDB00622 APRD00088
VerapamilDB00661 APRD00335
NitrendipineDB01054 APRD00421
NifedipineDB01115 APRD00590
MibefradilDB01388 -
DronedaroneDB04855 -
ClevidipineDB04920 -
NilvadipineDB06712 -
SpironolactoneDB00421 APRD01234

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.