HCSGD entry for CACNA1C

1. General information

Official gene symbolCACNA1C
Entrez ID775
Gene full namecalcium channel, voltage-dependent, L type, alpha 1C subunit
Other gene symbolsCACH2 CACN2 CACNL1A1 CCHL1A1 CaV1.2 LQT8 TS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002095Caveolar macromolecular signaling complexIEAcellular_component
GO:0005245Voltage-gated calcium channel activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005891Voltage-gated calcium channel complexIDA IEAcellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIDAbiological_process
GO:0007268Synaptic transmissionIEAbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007628Adult walking behaviorIEAbiological_process
GO:0008217Regulation of blood pressureIEAbiological_process
GO:0008331High voltage-gated calcium channel activityTASmolecular_function
GO:0008542Visual learningIEAbiological_process
GO:0010881Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionTASbiological_process
GO:0014069Postsynaptic densityIDAcellular_component
GO:0016021Integral component of membraneIDAcellular_component
GO:0017156Calcium ion-dependent exocytosisIEAbiological_process
GO:0019229Regulation of vasoconstrictionIEAbiological_process
GO:0030018Z discISScellular_component
GO:0030073Insulin secretionIEAbiological_process
GO:0030252Growth hormone secretionIEAbiological_process
GO:0035585Calcium-mediated signaling using extracellular calcium sourceTASbiological_process
GO:0042593Glucose homeostasisIEAbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043198Dendritic shaftIEAcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046620Regulation of organ growthIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0051393Alpha-actinin bindingIPImolecular_function
GO:0060083Smooth muscle contraction involved in micturitionIEAbiological_process
GO:0060402Calcium ion transport into cytosolTASbiological_process
GO:0086064Cell communication by electrical coupling involved in cardiac conductionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.60620586220.40059925150.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1269423749
GSE13712_SHEARUp0.0073841788
GSE13712_STATICUp0.0342001547
GSE19018Up0.0344808208
GSE19899_A1Down-0.0579454304
GSE19899_A2Down-0.1126974165
PubMed_21979375_A1Down-0.1097276249
PubMed_21979375_A2Down-0.1461768699
GSE35957Up0.5331020234
GSE36640Up0.2369877987
GSE54402Up0.0879597988
GSE9593Up0.2777230439
GSE43922Down-0.2841758915
GSE24585Down-0.1072042837
GSE37065Down-0.3252648236
GSE28863_A1Up0.3251375359
GSE28863_A2Down-0.1985171028
GSE28863_A3Up0.3302215705
GSE28863_A4Down-0.1078663282
GSE48662Up0.1579985738

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

IsradipineDB00270 APRD00298
IbutilideDB00308 APRD01025
NisoldipineDB00401 APRD00635
CinnarizineDB00568 APRD00332
NicardipineDB00622 APRD00088
Magnesium SulfateDB00653 APRD01080
VerapamilDB00661 APRD00335
NitrendipineDB01054 APRD00421
NifedipineDB01115 APRD00590
CalciumDB01373 -
MibefradilDB01388 -
DronedaroneDB04855 -
ClevidipineDB04920 -
NilvadipineDB06712 -
DrotaverineDB06751 -
SpironolactoneDB00421 APRD01234

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-133a-3pMIMAT0000427MIRT001203Luciferase reporter assay//Western blotFunctional MTI19136465
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.