HCSGD entry for CACNA1C

1. General information

Official gene symbolCACNA1C
Entrez ID775
Gene full namecalcium channel, voltage-dependent, L type, alpha 1C subunit
Other gene symbolsCACH2 CACN2 CACNL1A1 CCHL1A1 CaV1.2 LQT8 TS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002095Caveolar macromolecular signaling complexIEAcellular_component
GO:0005245Voltage-gated calcium channel activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005891Voltage-gated calcium channel complexIDA IEAcellular_component
GO:0006112Energy reserve metabolic processTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIDAbiological_process
GO:0007268Synaptic transmissionIEAbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007628Adult walking behaviorIEAbiological_process
GO:0008217Regulation of blood pressureIEAbiological_process
GO:0008331High voltage-gated calcium channel activityTASmolecular_function
GO:0008542Visual learningIEAbiological_process
GO:0010881Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionTASbiological_process
GO:0014069Postsynaptic densityIDAcellular_component
GO:0016021Integral component of membraneIDAcellular_component
GO:0017156Calcium ion-dependent exocytosisIEAbiological_process
GO:0019229Regulation of vasoconstrictionIEAbiological_process
GO:0030018Z discISScellular_component
GO:0030073Insulin secretionIEAbiological_process
GO:0030252Growth hormone secretionIEAbiological_process
GO:0035585Calcium-mediated signaling using extracellular calcium sourceTASbiological_process
GO:0042593Glucose homeostasisIEAbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043198Dendritic shaftIEAcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046620Regulation of organ growthIEAbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050796Regulation of insulin secretionTASbiological_process
GO:0051393Alpha-actinin bindingIPImolecular_function
GO:0060083Smooth muscle contraction involved in micturitionIEAbiological_process
GO:0060402Calcium ion transport into cytosolTASbiological_process
GO:0086064Cell communication by electrical coupling involved in cardiac conductionTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.60620586220.40059925150.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1269423749
GSE13712_SHEARUp0.0073841788
GSE13712_STATICUp0.0342001547
GSE19018Up0.0344808208
GSE19899_A1Down-0.0579454304
GSE19899_A2Down-0.1126974165
PubMed_21979375_A1Down-0.1097276249
PubMed_21979375_A2Down-0.1461768699
GSE35957Up0.5331020234
GSE36640Up0.2369877987
GSE54402Up0.0879597988
GSE9593Up0.2777230439
GSE43922Down-0.2841758915
GSE24585Down-0.1072042837
GSE37065Down-0.3252648236
GSE28863_A1Up0.3251375359
GSE28863_A2Down-0.1985171028
GSE28863_A3Up0.3302215705
GSE28863_A4Down-0.1078663282
GSE48662Up0.1579985738

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

IsradipineDB00270 APRD00298
IbutilideDB00308 APRD01025
NisoldipineDB00401 APRD00635
CinnarizineDB00568 APRD00332
NicardipineDB00622 APRD00088
Magnesium SulfateDB00653 APRD01080
VerapamilDB00661 APRD00335
NitrendipineDB01054 APRD00421
NifedipineDB01115 APRD00590
CalciumDB01373 -
MibefradilDB01388 -
DronedaroneDB04855 -
ClevidipineDB04920 -
NilvadipineDB06712 -
DrotaverineDB06751 -
SpironolactoneDB00421 APRD01234

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-133a-3pMIMAT0000427MIRT001203Luciferase reporter assay//Western blotFunctional MTI19136465
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.