HCSGD entry for YWHAE

1. General information

Official gene symbolYWHAE
Entrez ID7531
Gene full nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
Other gene symbols14-3-3E KCIP-1 MDCR MDS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0001764Neuron migrationIEAbiological_process
GO:0003064Regulation of heart rate by hormoneNASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005871Kinesin complexIEAcellular_component
GO:0006605Protein targetingIEAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0015459Potassium channel regulator activityIDAmolecular_function
GO:0016032Viral processIEAbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0021766Hippocampus developmentIEAbiological_process
GO:0021987Cerebral cortex developmentIEAbiological_process
GO:0030659Cytoplasmic vesicle membraneTAScellular_component
GO:0032403Protein complex bindingIEAmolecular_function
GO:0035329Hippo signalingTASbiological_process
GO:0035556Intracellular signal transductionTASbiological_process
GO:0042470MelanosomeIEAcellular_component
GO:0042826Histone deacetylase bindingIPImolecular_function
GO:0043281Regulation of cysteine-type endopeptidase activity involved in apoptotic processTASbiological_process
GO:0044325Ion channel bindingIPImolecular_function
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050815Phosphoserine bindingIPImolecular_function
GO:0051219Phosphoprotein bindingIPImolecular_function
GO:0060306Regulation of membrane repolarizationIDAbiological_process
GO:0070062Extracellular vesicular exosomeIDAcellular_component
GO:0086013Membrane repolarization during cardiac muscle cell action potentialICbiological_process
GO:0086091Regulation of heart rate by cardiac conductionICbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
GO:0097193Intrinsic apoptotic signaling pathwayTASbiological_process
GO:1900740Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayTASbiological_process
GO:1901016Regulation of potassium ion transmembrane transporter activityIDAbiological_process
GO:1902309Negative regulation of peptidyl-serine dephosphorylationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.69975584890.28692767370.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2784040198
GSE13712_SHEARUp0.1798409321
GSE13712_STATICUp0.0048640558
GSE19018Down-0.1406751456
GSE19899_A1Down-0.0533926361
GSE19899_A2Up0.0697391526
PubMed_21979375_A1Down-0.2960022353
PubMed_21979375_A2Up0.2357459066
GSE35957Up0.4041854887
GSE36640Down-0.2865602130
GSE54402Up0.0641522757
GSE9593Down-0.0651465177
GSE43922Down-0.1769168675
GSE24585Up0.0756842447
GSE37065Down-0.0164743078
GSE28863_A1Up0.1557228129
GSE28863_A2Down-0.2850054483
GSE28863_A3Up0.0093481685
GSE28863_A4Up0.0569025368
GSE48662Down-0.0831004665

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

FusicoccinDB01780 EXPT01498

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30a-5pMIMAT0000087MIRT028656ProteomicsFunctional MTI (Weak)18668040
hsa-miR-877-3pMIMAT0004950MIRT036929CLASHFunctional MTI (Weak)23622248
hsa-miR-92b-3pMIMAT0003218MIRT040587CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041963CLASHFunctional MTI (Weak)23622248
hsa-miR-30e-3pMIMAT0000693MIRT044125CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044734CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT045171CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045527CLASHFunctional MTI (Weak)23622248
hsa-miR-221-3pMIMAT0000278MIRT046839CLASHFunctional MTI (Weak)23622248
hsa-miR-100-5pMIMAT0000098MIRT048386CLASHFunctional MTI (Weak)23622248
hsa-miR-30a-3pMIMAT0000088MIRT049920CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050142CLASHFunctional MTI (Weak)23622248
hsa-let-7e-5pMIMAT0000066MIRT051565CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT051964CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.