HCSGD entry for YWHAE

1. General information

Official gene symbolYWHAE
Entrez ID7531
Gene full nametyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
Other gene symbols14-3-3E KCIP-1 MDCR MDS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0001764Neuron migrationIEAbiological_process
GO:0003064Regulation of heart rate by hormoneNASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005739MitochondrionIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005871Kinesin complexIEAcellular_component
GO:0006605Protein targetingIEAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0015459Potassium channel regulator activityIDAmolecular_function
GO:0016032Viral processIEAbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0019904Protein domain specific bindingIEAmolecular_function
GO:0021766Hippocampus developmentIEAbiological_process
GO:0021987Cerebral cortex developmentIEAbiological_process
GO:0030659Cytoplasmic vesicle membraneTAScellular_component
GO:0032403Protein complex bindingIEAmolecular_function
GO:0035329Hippo signalingTASbiological_process
GO:0035556Intracellular signal transductionTASbiological_process
GO:0042470MelanosomeIEAcellular_component
GO:0042826Histone deacetylase bindingIPImolecular_function
GO:0043281Regulation of cysteine-type endopeptidase activity involved in apoptotic processTASbiological_process
GO:0044325Ion channel bindingIPImolecular_function
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0050815Phosphoserine bindingIPImolecular_function
GO:0051219Phosphoprotein bindingIPImolecular_function
GO:0060306Regulation of membrane repolarizationIDAbiological_process
GO:0070062Extracellular vesicular exosomeIDAcellular_component
GO:0086013Membrane repolarization during cardiac muscle cell action potentialICbiological_process
GO:0086091Regulation of heart rate by cardiac conductionICbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
GO:0097193Intrinsic apoptotic signaling pathwayTASbiological_process
GO:1900740Positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayTASbiological_process
GO:1901016Regulation of potassium ion transmembrane transporter activityIDAbiological_process
GO:1902309Negative regulation of peptidyl-serine dephosphorylationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.69975584890.28692767370.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2784040198
GSE13712_SHEARUp0.1798409321
GSE13712_STATICUp0.0048640558
GSE19018Down-0.1406751456
GSE19899_A1Down-0.0533926361
GSE19899_A2Up0.0697391526
PubMed_21979375_A1Down-0.2960022353
PubMed_21979375_A2Up0.2357459066
GSE35957Up0.4041854887
GSE36640Down-0.2865602130
GSE54402Up0.0641522757
GSE9593Down-0.0651465177
GSE43922Down-0.1769168675
GSE24585Up0.0756842447
GSE37065Down-0.0164743078
GSE28863_A1Up0.1557228129
GSE28863_A2Down-0.2850054483
GSE28863_A3Up0.0093481685
GSE28863_A4Up0.0569025368
GSE48662Down-0.0831004665

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

FusicoccinDB01780 EXPT01498

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-30a-5pMIMAT0000087MIRT028656ProteomicsFunctional MTI (Weak)18668040
hsa-miR-877-3pMIMAT0004950MIRT036929CLASHFunctional MTI (Weak)23622248
hsa-miR-92b-3pMIMAT0003218MIRT040587CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041963CLASHFunctional MTI (Weak)23622248
hsa-miR-30e-3pMIMAT0000693MIRT044125CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044734CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT045171CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045527CLASHFunctional MTI (Weak)23622248
hsa-miR-221-3pMIMAT0000278MIRT046839CLASHFunctional MTI (Weak)23622248
hsa-miR-100-5pMIMAT0000098MIRT048386CLASHFunctional MTI (Weak)23622248
hsa-miR-30a-3pMIMAT0000088MIRT049920CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050142CLASHFunctional MTI (Weak)23622248
hsa-let-7e-5pMIMAT0000066MIRT051565CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT051964CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.