HCSGD entry for YY1
1. General information
| Official gene symbol | YY1 |
|---|---|
| Entrez ID | 7528 |
| Gene full name | YY1 transcription factor |
| Other gene symbols | DELTA INO80S NF-E1 UCRBP YIN-YANG-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0000400 | Four-way junction DNA binding | IDA | molecular_function |
| GO:0000724 | Double-strand break repair via homologous recombination | IMP | biological_process |
| GO:0001078 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription | IEA ISS | molecular_function |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IDA IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | TAS | molecular_function |
| GO:0003713 | Transcription coactivator activity | TAS | molecular_function |
| GO:0003714 | Transcription corepressor activity | TAS | molecular_function |
| GO:0003723 | RNA binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | ISS | biological_process |
| GO:0006403 | RNA localization | IEA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IEA IMP | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0008270 | Zinc ion binding | TAS | molecular_function |
| GO:0009952 | Anterior/posterior pattern specification | IEA | biological_process |
| GO:0010225 | Response to UV-C | IEA IMP | biological_process |
| GO:0016363 | Nuclear matrix | IEA | cellular_component |
| GO:0030154 | Cell differentiation | IEA | biological_process |
| GO:0031011 | Ino80 complex | IDA | cellular_component |
| GO:0031519 | PcG protein complex | IEA | cellular_component |
| GO:0034644 | Cellular response to UV | IMP | biological_process |
| GO:0034696 | Response to prostaglandin F | IEA | biological_process |
| GO:0044212 | Transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048593 | Camera-type eye morphogenesis | IEA | biological_process |
| GO:0051276 | Chromosome organization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7223857832 | 0.7168277307 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0693123713 |
| GSE13712_SHEAR | Down | -0.0645722234 |
| GSE13712_STATIC | Down | -0.1488031884 |
| GSE19018 | Up | 0.3379303988 |
| GSE19899_A1 | Down | -0.0484132836 |
| GSE19899_A2 | Up | 0.0752598896 |
| PubMed_21979375_A1 | Down | -0.6507596759 |
| PubMed_21979375_A2 | Up | 0.0075093129 |
| GSE35957 | Down | -0.0511360240 |
| GSE36640 | Up | 0.0165628330 |
| GSE54402 | Up | 0.0226968018 |
| GSE9593 | Up | 0.0515092408 |
| GSE43922 | Down | -0.0349397852 |
| GSE24585 | Up | 0.1307864220 |
| GSE37065 | Up | 0.0278579074 |
| GSE28863_A1 | Up | 0.0902771178 |
| GSE28863_A2 | Up | 0.2913215626 |
| GSE28863_A3 | Down | -0.1343471675 |
| GSE28863_A4 | Up | 0.0441466327 |
| GSE48662 | Down | -0.0391262101 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT004045 | Luciferase reporter assay//Western blot//Reporter assay | Functional MTI | 21182263 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT004045 | Reporter assay;Proteomics | Functional MTI | 21566225 |
| hsa-miR-31-5p | MIMAT0000089 | MIRT004968 | Luciferase reporter assay//qRT-PCR | Non-Functional MTI | 19524507 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028073 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT028073 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-3p | MIMAT0003887 | MIRT039108 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040246 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041821 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043278 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046848 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22391813 | As a member of the GLI-Kruppel family of transcriptional factors, Yin Yang-1 (YY1) functions as an oncogene in various types of cancers |
| 22391813 | Ectopic YY1 expression promoted the growth of non-tumor liver cells that expressed low level of YY1 |
| 22391813 | In contrast, YY1 depletion inhibited the growth of HCC cells which was accompanied with distinct morphological changes |
| 22391813 | Moreover, the phenotypic changes induced by YY1 depletion were attributed to cellular differentiation rather than cellular senescence |
| 22391813 | CCAAT/enhancer-binding protein alpha (CEBPA) which was important to regulate differentiation of hepatocytes was found as the direct target downregulated by YY1 |
| 22391813 | In summary, our study demonstrated that YY1 could promote hepatocellular carcinogenesis and inhibit cellular differentiation through the downregulation of CEBPA expression |
| 18558095 | The transcription factor YY1 has been implicated to play a role in cell growth control |
| 18558095 | In this report, we demonstrate that YY1 was able to suppress NCI-H460 cell senescence through regulating the expression of p16(INK4a), a cyclin-dependent kinase inhibitor |
| 18558095 | We also show that YY1 participated in the repression of p16(INK4a) expression in 293T cells through an epigenetic mechanism involving histone acetylation modification |
| 18558095 | The chromatin immunoprecipitation (ChIP) assays verified that HDAC3 and HDAC4 were recruited to p16(INK4a) promoter by YY1 |
| 18558095 | Overall, data from this study suggest that YY1, HDAC3 and HDAC4 restrained cell senescence by repressing p16(INK4a) expression through an epigenetic modification of histones |
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