HCSGD entry for YY1

1. General information

Official gene symbolYY1
Entrez ID7528
Gene full nameYY1 transcription factor
Other gene symbolsDELTA INO80S NF-E1 UCRBP YIN-YANG-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000400Four-way junction DNA bindingIDAmolecular_function
GO:0000724Double-strand break repair via homologous recombinationIMPbiological_process
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIEA ISSmolecular_function
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003677DNA bindingIDA IEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0003713Transcription coactivator activityTASmolecular_function
GO:0003714Transcription corepressor activityTASmolecular_function
GO:0003723RNA bindingIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006366Transcription from RNA polymerase II promoterISSbiological_process
GO:0006403RNA localizationIEAbiological_process
GO:0006974Cellular response to DNA damage stimulusIEA IMPbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0008270Zinc ion bindingTASmolecular_function
GO:0009952Anterior/posterior pattern specificationIEAbiological_process
GO:0010225Response to UV-CIEA IMPbiological_process
GO:0016363Nuclear matrixIEAcellular_component
GO:0030154Cell differentiationIEAbiological_process
GO:0031011Ino80 complexIDAcellular_component
GO:0031519PcG protein complexIEAcellular_component
GO:0034644Cellular response to UVIMPbiological_process
GO:0034696Response to prostaglandin FIEAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048593Camera-type eye morphogenesisIEAbiological_process
GO:0051276Chromosome organizationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.72238578320.71682773070.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0693123713
GSE13712_SHEARDown-0.0645722234
GSE13712_STATICDown-0.1488031884
GSE19018Up0.3379303988
GSE19899_A1Down-0.0484132836
GSE19899_A2Up0.0752598896
PubMed_21979375_A1Down-0.6507596759
PubMed_21979375_A2Up0.0075093129
GSE35957Down-0.0511360240
GSE36640Up0.0165628330
GSE54402Up0.0226968018
GSE9593Up0.0515092408
GSE43922Down-0.0349397852
GSE24585Up0.1307864220
GSE37065Up0.0278579074
GSE28863_A1Up0.0902771178
GSE28863_A2Up0.2913215626
GSE28863_A3Down-0.1343471675
GSE28863_A4Up0.0441466327
GSE48662Down-0.0391262101

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-34a-5pMIMAT0000255MIRT004045Luciferase reporter assay//Western blot//Reporter assayFunctional MTI21182263
hsa-miR-34a-5pMIMAT0000255MIRT004045Reporter assay;ProteomicsFunctional MTI21566225
hsa-miR-31-5pMIMAT0000089MIRT004968Luciferase reporter assay//qRT-PCRNon-Functional MTI19524507
hsa-miR-93-5pMIMAT0000093MIRT028073SequencingFunctional MTI (Weak)20371350
hsa-miR-93-5pMIMAT0000093MIRT028073CLASHFunctional MTI (Weak)23622248
hsa-miR-769-3pMIMAT0003887MIRT039108CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040246CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041821CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043278CLASHFunctional MTI (Weak)23622248
hsa-miR-221-3pMIMAT0000278MIRT046848CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22391813As a member of the GLI-Kruppel family of transcriptional factors, Yin Yang-1 (YY1) functions as an oncogene in various types of cancers
22391813Ectopic YY1 expression promoted the growth of non-tumor liver cells that expressed low level of YY1
22391813In contrast, YY1 depletion inhibited the growth of HCC cells which was accompanied with distinct morphological changes
22391813Moreover, the phenotypic changes induced by YY1 depletion were attributed to cellular differentiation rather than cellular senescence
22391813CCAAT/enhancer-binding protein alpha (CEBPA) which was important to regulate differentiation of hepatocytes was found as the direct target downregulated by YY1
22391813In summary, our study demonstrated that YY1 could promote hepatocellular carcinogenesis and inhibit cellular differentiation through the downregulation of CEBPA expression
18558095The transcription factor YY1 has been implicated to play a role in cell growth control
18558095In this report, we demonstrate that YY1 was able to suppress NCI-H460 cell senescence through regulating the expression of p16(INK4a), a cyclin-dependent kinase inhibitor
18558095We also show that YY1 participated in the repression of p16(INK4a) expression in 293T cells through an epigenetic mechanism involving histone acetylation modification
18558095The chromatin immunoprecipitation (ChIP) assays verified that HDAC3 and HDAC4 were recruited to p16(INK4a) promoter by YY1
18558095Overall, data from this study suggest that YY1, HDAC3 and HDAC4 restrained cell senescence by repressing p16(INK4a) expression through an epigenetic modification of histones
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