HCSGD entry for XBP1
1. General information
| Official gene symbol | XBP1 |
|---|---|
| Entrez ID | 7494 |
| Gene full name | X-box binding protein 1 |
| Other gene symbols | TREB5 XBP-1 XBP2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0006987 | Activation of signaling protein activity involved in unfolded protein response | TAS | biological_process |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0031017 | Exocrine pancreas development | IEA | biological_process |
| GO:0042493 | Response to drug | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0051602 | Response to electrical stimulus | IEA | biological_process |
| GO:0060096 | Serotonin secretion, neurotransmission | IEA | biological_process |
| GO:0060691 | Epithelial cell maturation involved in salivary gland development | IEA | biological_process |
| GO:0071236 | Cellular response to antibiotic | IEA | biological_process |
| GO:1900103 | Positive regulation of endoplasmic reticulum unfolded protein response | IMP | biological_process |
Entries Per Page
Displaying Page of
4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3224745716 | 0.4975303674 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2920778553 |
| GSE13712_SHEAR | Up | 0.0062043602 |
| GSE13712_STATIC | Up | 0.0986425459 |
| GSE19018 | Down | -0.1558231400 |
| GSE19899_A1 | Up | 0.1313369087 |
| GSE19899_A2 | Up | 0.0835566488 |
| PubMed_21979375_A1 | Up | 0.1636722527 |
| PubMed_21979375_A2 | Down | -0.0463959213 |
| GSE35957 | Down | -0.1494758442 |
| GSE36640 | Up | 0.1003353083 |
| GSE54402 | Down | -0.4975734880 |
| GSE9593 | Down | -0.4379507432 |
| GSE43922 | Up | 0.1492763893 |
| GSE24585 | Up | 0.6487984182 |
| GSE37065 | Up | 0.1831548834 |
| GSE28863_A1 | Up | 0.2487441360 |
| GSE28863_A2 | Up | 0.3159128369 |
| GSE28863_A3 | Down | -0.2977636314 |
| GSE28863_A4 | Up | 0.1499607149 |
| GSE48662 | Down | -0.2328110114 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-214-3p | MIMAT0000271 | MIRT006375 | ELISA//Flow//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22359598 |
| hsa-miR-127-3p | MIMAT0000446 | MIRT004462 | Luciferase reporter assay | Functional MTI | 19530237 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022880 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-625-3p | MIMAT0004808 | MIRT037784 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044687 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048823 | CLASH | Functional MTI (Weak) | 23622248 |
Entries Per Page
Displaying Page of
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26515130 | The UPR resulted in upregulation of ER chaperones including BIP/Grp78, Grp94 and led to an activation of IRE1alpha as evidenced by spliced XBP1 mRNA with IRE1alpha-induced JNK phosphorylation |
| 22957041 | Worms lacking both ICD-1 and the UPR transcription factor XBP-1 generated a higher proportion of defective embryos, showed increased embryonic apoptosis and had a diminished survival rate relative to ICD-1-depleted animals with an intact UPR |
Entries Per Page
Displaying Page of
