HCSGD entry for XBP1

1. General information

Official gene symbolXBP1
Entrez ID7494
Gene full nameX-box binding protein 1
Other gene symbolsTREB5 XBP-1 XBP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003677DNA bindingTASmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0006366Transcription from RNA polymerase II promoterIEAbiological_process
GO:0006955Immune responseTASbiological_process
GO:0006987Activation of signaling protein activity involved in unfolded protein responseTASbiological_process
GO:0030968Endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0031017Exocrine pancreas developmentIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0051602Response to electrical stimulusIEAbiological_process
GO:0060096Serotonin secretion, neurotransmissionIEAbiological_process
GO:0060691Epithelial cell maturation involved in salivary gland developmentIEAbiological_process
GO:0071236Cellular response to antibioticIEAbiological_process
GO:1900103Positive regulation of endoplasmic reticulum unfolded protein responseIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.32247457160.49753036740.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2920778553
GSE13712_SHEARUp0.0062043602
GSE13712_STATICUp0.0986425459
GSE19018Down-0.1558231400
GSE19899_A1Up0.1313369087
GSE19899_A2Up0.0835566488
PubMed_21979375_A1Up0.1636722527
PubMed_21979375_A2Down-0.0463959213
GSE35957Down-0.1494758442
GSE36640Up0.1003353083
GSE54402Down-0.4975734880
GSE9593Down-0.4379507432
GSE43922Up0.1492763893
GSE24585Up0.6487984182
GSE37065Up0.1831548834
GSE28863_A1Up0.2487441360
GSE28863_A2Up0.3159128369
GSE28863_A3Down-0.2977636314
GSE28863_A4Up0.1499607149
GSE48662Down-0.2328110114

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-214-3pMIMAT0000271MIRT006375ELISA//Flow//Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI22359598
hsa-miR-127-3pMIMAT0000446MIRT004462Luciferase reporter assayFunctional MTI19530237
hsa-miR-124-3pMIMAT0000422MIRT022880MicroarrayFunctional MTI (Weak)18668037
hsa-miR-625-3pMIMAT0004808MIRT037784CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044687CLASHFunctional MTI (Weak)23622248
hsa-miR-93-5pMIMAT0000093MIRT048823CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26515130The UPR resulted in upregulation of ER chaperones including BIP/Grp78, Grp94 and led to an activation of IRE1alpha as evidenced by spliced XBP1 mRNA with IRE1alpha-induced JNK phosphorylation
22957041Worms lacking both ICD-1 and the UPR transcription factor XBP-1 generated a higher proportion of defective embryos, showed increased embryonic apoptosis and had a diminished survival rate relative to ICD-1-depleted animals with an intact UPR
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