HCSGD entry for VAV2

1. General information

Official gene symbolVAV2
Entrez ID7410
Gene full namevav 2 guanine nucleotide exchange factor
Other gene symbolsVAV-2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0005085Guanyl-nucleotide exchange factor activityEXP TASmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005154Epidermal growth factor receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0016477Cell migrationIEAbiological_process
GO:0030032Lamellipodium assemblyIEAbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043087Regulation of GTPase activityEXP TASbiological_process
GO:0043552Positive regulation of phosphatidylinositol 3-kinase activityIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48286326510.49309148970.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0855247300
GSE13712_SHEARUp0.4999075224
GSE13712_STATICUp0.1254041594
GSE19018Down-0.1241501637
GSE19899_A1Down-0.0572415479
GSE19899_A2Down-0.0368838358
PubMed_21979375_A1Down-0.1358023325
PubMed_21979375_A2Down-0.3013302319
GSE35957Down-0.5274821137
GSE36640Down-0.1402412235
GSE54402Up0.1061946785
GSE9593Down-0.0958626191
GSE43922Down-0.0110589947
GSE24585Up0.4922786891
GSE37065Down-0.0840749268
GSE28863_A1Up0.5078623169
GSE28863_A2Up0.4048393285
GSE28863_A3Down-0.1029431510
GSE28863_A4Up0.0380817549
GSE48662Down-0.0026660264

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020809ProteomicsFunctional MTI (Weak)18668040
hsa-miR-877-3pMIMAT0004950MIRT036995CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041420CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044622CLASHFunctional MTI (Weak)23622248
hsa-let-7a-5pMIMAT0000062MIRT052458CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.