HCSGD entry for VAV2

1. General information

Official gene symbolVAV2
Entrez ID7410
Gene full namevav 2 guanine nucleotide exchange factor
Other gene symbolsVAV-2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001525AngiogenesisIEAbiological_process
GO:0005085Guanyl-nucleotide exchange factor activityEXP TASmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005154Epidermal growth factor receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0007411Axon guidanceTASbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0016477Cell migrationIEAbiological_process
GO:0030032Lamellipodium assemblyIEAbiological_process
GO:0030168Platelet activationTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTASbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043087Regulation of GTPase activityEXP TASbiological_process
GO:0043552Positive regulation of phosphatidylinositol 3-kinase activityIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.48286326510.49309148970.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0855247300
GSE13712_SHEARUp0.4999075224
GSE13712_STATICUp0.1254041594
GSE19018Down-0.1241501637
GSE19899_A1Down-0.0572415479
GSE19899_A2Down-0.0368838358
PubMed_21979375_A1Down-0.1358023325
PubMed_21979375_A2Down-0.3013302319
GSE35957Down-0.5274821137
GSE36640Down-0.1402412235
GSE54402Up0.1061946785
GSE9593Down-0.0958626191
GSE43922Down-0.0110589947
GSE24585Up0.4922786891
GSE37065Down-0.0840749268
GSE28863_A1Up0.5078623169
GSE28863_A2Up0.4048393285
GSE28863_A3Down-0.1029431510
GSE28863_A4Up0.0380817549
GSE48662Down-0.0026660264

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-5pMIMAT0000646MIRT020809ProteomicsFunctional MTI (Weak)18668040
hsa-miR-877-3pMIMAT0004950MIRT036995CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041420CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044622CLASHFunctional MTI (Weak)23622248
hsa-let-7a-5pMIMAT0000062MIRT052458CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.