HCSGD entry for C5

1. General information

Official gene symbolC5
Entrez ID727
Gene full namecomplement component 5
Other gene symbolsC5a C5b CPAMD4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityTASbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0002523Leukocyte migration involved in inflammatory responseIEAbiological_process
GO:0004866Endopeptidase inhibitor activityIEAmolecular_function
GO:0005102Receptor bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005579Membrane attack complexIEAcellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006874Cellular calcium ion homeostasisIEAbiological_process
GO:0006935ChemotaxisTASbiological_process
GO:0006950Response to stressTASbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0006956Complement activationTASbiological_process
GO:0006957Complement activation, alternative pathwayIEAbiological_process
GO:0006958Complement activation, classical pathwayIEAbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0008009Chemokine activityTASmolecular_function
GO:0010575Positive regulation vascular endothelial growth factor productionIDAbiological_process
GO:0010700Negative regulation of norepinephrine secretionIEAbiological_process
GO:0010760Negative regulation of macrophage chemotaxisIDAbiological_process
GO:0019835CytolysisIEAbiological_process
GO:0030449Regulation of complement activationTASbiological_process
GO:0031714C5a anaphylatoxin chemotactic receptor bindingIEAmolecular_function
GO:0033602Negative regulation of dopamine secretionIEAbiological_process
GO:0042593Glucose homeostasisIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045766Positive regulation of angiogenesisIEAbiological_process
GO:0050921Positive regulation of chemotaxisIEAbiological_process
GO:0060326Cell chemotaxisTASbiological_process
GO:0090197Positive regulation of chemokine secretionIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.51519653890.01005787390.99999024730.1989456864

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0778341701
GSE13712_SHEARDown-0.2973853633
GSE13712_STATICDown-0.0453248354
GSE19018Down-0.2467583606
GSE19899_A1Down-0.0874696147
GSE19899_A2Down-1.1864330564
PubMed_21979375_A1Down-1.2628827627
PubMed_21979375_A2Down-0.8833546742
GSE35957Down-0.9287038200
GSE36640Down-1.3314772341
GSE54402Down-0.5761767597
GSE9593Down-0.6151630091
GSE43922Down-1.1729742129
GSE24585Up1.4003231819
GSE37065Down-0.1034994562
GSE28863_A1Up0.7818117083
GSE28863_A2Up0.4665089566
GSE28863_A3Down-0.1230748885
GSE28863_A4Up0.1578177515
GSE48662Down-0.2212961996

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Immune Globulin HumanDB00028 BTD00091 | BIOD00091
EculizumabDB01257 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016535MicroarrayFunctional MTI (Weak)20304954
hsa-miR-10a-5pMIMAT0000253MIRT047564CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.