HCSGD entry for C5

1. General information

Official gene symbolC5
Entrez ID727
Gene full namecomplement component 5
Other gene symbolsC5a C5b CPAMD4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityTASbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0002523Leukocyte migration involved in inflammatory responseIEAbiological_process
GO:0004866Endopeptidase inhibitor activityIEAmolecular_function
GO:0005102Receptor bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005579Membrane attack complexIEAcellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006874Cellular calcium ion homeostasisIEAbiological_process
GO:0006935ChemotaxisTASbiological_process
GO:0006950Response to stressTASbiological_process
GO:0006954Inflammatory responseTASbiological_process
GO:0006956Complement activationTASbiological_process
GO:0006957Complement activation, alternative pathwayIEAbiological_process
GO:0006958Complement activation, classical pathwayIEAbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0008009Chemokine activityTASmolecular_function
GO:0010575Positive regulation vascular endothelial growth factor productionIDAbiological_process
GO:0010700Negative regulation of norepinephrine secretionIEAbiological_process
GO:0010760Negative regulation of macrophage chemotaxisIDAbiological_process
GO:0019835CytolysisIEAbiological_process
GO:0030449Regulation of complement activationTASbiological_process
GO:0031714C5a anaphylatoxin chemotactic receptor bindingIEAmolecular_function
GO:0033602Negative regulation of dopamine secretionIEAbiological_process
GO:0042593Glucose homeostasisIEAbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045766Positive regulation of angiogenesisIEAbiological_process
GO:0050921Positive regulation of chemotaxisIEAbiological_process
GO:0060326Cell chemotaxisTASbiological_process
GO:0090197Positive regulation of chemokine secretionIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.51519653890.01005787390.99999024730.1989456864

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0778341701
GSE13712_SHEARDown-0.2973853633
GSE13712_STATICDown-0.0453248354
GSE19018Down-0.2467583606
GSE19899_A1Down-0.0874696147
GSE19899_A2Down-1.1864330564
PubMed_21979375_A1Down-1.2628827627
PubMed_21979375_A2Down-0.8833546742
GSE35957Down-0.9287038200
GSE36640Down-1.3314772341
GSE54402Down-0.5761767597
GSE9593Down-0.6151630091
GSE43922Down-1.1729742129
GSE24585Up1.4003231819
GSE37065Down-0.1034994562
GSE28863_A1Up0.7818117083
GSE28863_A2Up0.4665089566
GSE28863_A3Down-0.1230748885
GSE28863_A4Up0.1578177515
GSE48662Down-0.2212961996

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Immune Globulin HumanDB00028 BTD00091 | BIOD00091
EculizumabDB01257 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT016535MicroarrayFunctional MTI (Weak)20304954
hsa-miR-10a-5pMIMAT0000253MIRT047564CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.