HCSGD entry for TSHR

1. General information

Official gene symbolTSHR
Entrez ID7253
Gene full namethyroid stimulating hormone receptor
Other gene symbolsCHNG1 LGR3 hTSHR-I
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004996Thyroid-stimulating hormone receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneIEA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerTASbiological_process
GO:0007189Adenylate cyclase-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0008344Adult locomotory behaviorIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0030183B cell differentiationIEAbiological_process
GO:0038194Thyroid-stimulating hormone signaling pathwayTASbiological_process
GO:0040012Regulation of locomotionIEAbiological_process
GO:0040018Positive regulation of multicellular organism growthIEAbiological_process
GO:0043235Receptor complexIDAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.90441097980.72255337180.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0272120160
GSE13712_SHEARDown-0.0262919293
GSE13712_STATICUp0.0820420160
GSE19018Down-0.0846558890
GSE19899_A1Up0.0554109335
GSE19899_A2Down-0.0720140699
PubMed_21979375_A1Down-0.0033840894
PubMed_21979375_A2Up0.0184079750
GSE35957Down-0.0611672863
GSE36640Up0.1212868664
GSE54402Up0.0273870910
GSE9593Up0.0067331396
GSE43922Up0.0135109872
GSE24585Down-0.1786928921
GSE37065Down-0.0234541311
GSE28863_A1Down-0.0529047718
GSE28863_A2Down-0.1018134893
GSE28863_A3Up0.1631515681
GSE28863_A4Down-0.0085178068
GSE48662Down-0.0076100421

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Thyrotropin AlfaDB00024 BTD00020 | BIOD00020

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017856MicroarrayFunctional MTI (Weak)18185580
hsa-miR-1MIMAT0000416MIRT023731MicroarrayFunctional MTI (Weak)18668037
hsa-miR-181a-5pMIMAT0000256MIRT025045MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.