HCSGD entry for TSHR
1. General information
| Official gene symbol | TSHR |
|---|---|
| Entrez ID | 7253 |
| Gene full name | thyroid stimulating hormone receptor |
| Other gene symbols | CHNG1 LGR3 hTSHR-I |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004996 | Thyroid-stimulating hormone receptor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | IEA TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | TAS | biological_process |
| GO:0007189 | Adenylate cyclase-activating G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | TAS | biological_process |
| GO:0008344 | Adult locomotory behavior | IEA | biological_process |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030183 | B cell differentiation | IEA | biological_process |
| GO:0038194 | Thyroid-stimulating hormone signaling pathway | TAS | biological_process |
| GO:0040012 | Regulation of locomotion | IEA | biological_process |
| GO:0040018 | Positive regulation of multicellular organism growth | IEA | biological_process |
| GO:0043235 | Receptor complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9044109798 | 0.7225533718 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0272120160 |
| GSE13712_SHEAR | Down | -0.0262919293 |
| GSE13712_STATIC | Up | 0.0820420160 |
| GSE19018 | Down | -0.0846558890 |
| GSE19899_A1 | Up | 0.0554109335 |
| GSE19899_A2 | Down | -0.0720140699 |
| PubMed_21979375_A1 | Down | -0.0033840894 |
| PubMed_21979375_A2 | Up | 0.0184079750 |
| GSE35957 | Down | -0.0611672863 |
| GSE36640 | Up | 0.1212868664 |
| GSE54402 | Up | 0.0273870910 |
| GSE9593 | Up | 0.0067331396 |
| GSE43922 | Up | 0.0135109872 |
| GSE24585 | Down | -0.1786928921 |
| GSE37065 | Down | -0.0234541311 |
| GSE28863_A1 | Down | -0.0529047718 |
| GSE28863_A2 | Down | -0.1018134893 |
| GSE28863_A3 | Up | 0.1631515681 |
| GSE28863_A4 | Down | -0.0085178068 |
| GSE48662 | Down | -0.0076100421 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Thyrotropin Alfa | DB00024 | BTD00020 | BIOD00020 |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017856 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-1 | MIMAT0000416 | MIRT023731 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-181a-5p | MIMAT0000256 | MIRT025045 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
