HCSGD entry for TSC2

1. General information

Official gene symbolTSC2
Entrez ID7249
Gene full nametuberous sclerosis 2
Other gene symbolsLAM TSC4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0001843Neural tube closureISSbiological_process
GO:0005096GTPase activator activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0005901CaveolaIEAcellular_component
GO:0006469Negative regulation of protein kinase activityISSbiological_process
GO:0006606Protein import into nucleusISSbiological_process
GO:0006897EndocytosisTASbiological_process
GO:0006953Acute-phase responseIEAbiological_process
GO:0007050Cell cycle arrestTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007507Heart developmentISSbiological_process
GO:0008104Protein localizationISSbiological_process
GO:0008285Negative regulation of cell proliferationIBA ISSbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0014065Phosphatidylinositol 3-kinase signalingIEAbiological_process
GO:0014067Negative regulation of phosphatidylinositol 3-kinase signalingISSbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016192Vesicle-mediated transportTASbiological_process
GO:0019902Phosphatase bindingIDAmolecular_function
GO:0030030Cell projection organizationIEAbiological_process
GO:0030100Regulation of endocytosisISSbiological_process
GO:0030178Negative regulation of Wnt signaling pathwayIBAbiological_process
GO:0030425DendriteIEAcellular_component
GO:0030426Growth coneIEAcellular_component
GO:0032007Negative regulation of TOR signalingIBA IEAbiological_process
GO:0033596TSC1-TSC2 complexIDA IEAcellular_component
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043407Negative regulation of MAP kinase activityIEAbiological_process
GO:0043491Protein kinase B signalingIBA ISSbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045792Negative regulation of cell sizeIBAbiological_process
GO:0046626Regulation of insulin receptor signaling pathwayIBA ISSbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0048009Insulin-like growth factor receptor signaling pathwayIBA ISSbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050680Negative regulation of epithelial cell proliferationIEAbiological_process
GO:0050918Positive chemotaxisISSbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionIEAbiological_process
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0051726Regulation of cell cycleIBAbiological_process
GO:0051898Negative regulation of protein kinase B signalingISSbiological_process
GO:007188914-3-3 protein bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.08792246500.89549902740.62293598921.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0851653821
GSE13712_SHEARDown-0.0403629301
GSE13712_STATICDown-0.0030015301
GSE19018Down-0.0402432277
GSE19899_A1Down-0.1641740800
GSE19899_A2Down-0.0894800588
PubMed_21979375_A1Up1.0014163648
PubMed_21979375_A2Up1.3127227299
GSE35957Down-0.1072605224
GSE36640Up0.2294959288
GSE54402Up0.0382185852
GSE9593Up0.1782202329
GSE43922Down-0.2884896763
GSE24585Up0.3569209001
GSE37065Down-0.1678144052
GSE28863_A1Up0.4625382725
GSE28863_A2Up0.3923052061
GSE28863_A3Up0.2764583021
GSE28863_A4Up0.0224018362
GSE48662Up0.1719281937

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-744-5pMIMAT0004945MIRT037646CLASHFunctional MTI (Weak)23622248
hsa-miR-296-3pMIMAT0004679MIRT038502CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT050917CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26977878Inhibition of CDK4/6 not only suppresses Rb phosphorylation, but also reduces TSC2 phosphorylation and thus partially attenuates mTORC1 activity
26977878Consequently, dual inhibition of EGFR/HER2 and CDK4/6 invokes a more potent suppression of TSC2 phosphorylation and hence mTORC1/S6K/S6RP activity
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