HCSGD entry for TSC2

1. General information

Official gene symbolTSC2
Entrez ID7249
Gene full nametuberous sclerosis 2
Other gene symbolsLAM TSC4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0001843Neural tube closureISSbiological_process
GO:0005096GTPase activator activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0005901CaveolaIEAcellular_component
GO:0006469Negative regulation of protein kinase activityISSbiological_process
GO:0006606Protein import into nucleusISSbiological_process
GO:0006897EndocytosisTASbiological_process
GO:0006953Acute-phase responseIEAbiological_process
GO:0007050Cell cycle arrestTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0007507Heart developmentISSbiological_process
GO:0008104Protein localizationISSbiological_process
GO:0008285Negative regulation of cell proliferationIBA ISSbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0014065Phosphatidylinositol 3-kinase signalingIEAbiological_process
GO:0014067Negative regulation of phosphatidylinositol 3-kinase signalingISSbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016192Vesicle-mediated transportTASbiological_process
GO:0019902Phosphatase bindingIDAmolecular_function
GO:0030030Cell projection organizationIEAbiological_process
GO:0030100Regulation of endocytosisISSbiological_process
GO:0030178Negative regulation of Wnt signaling pathwayIBAbiological_process
GO:0030425DendriteIEAcellular_component
GO:0030426Growth coneIEAcellular_component
GO:0032007Negative regulation of TOR signalingIBA IEAbiological_process
GO:0033596TSC1-TSC2 complexIDA IEAcellular_component
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043407Negative regulation of MAP kinase activityIEAbiological_process
GO:0043491Protein kinase B signalingIBA ISSbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045792Negative regulation of cell sizeIBAbiological_process
GO:0046626Regulation of insulin receptor signaling pathwayIBA ISSbiological_process
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0048009Insulin-like growth factor receptor signaling pathwayIBA ISSbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0048471Perinuclear region of cytoplasmIDAcellular_component
GO:0050680Negative regulation of epithelial cell proliferationIEAbiological_process
GO:0050918Positive chemotaxisISSbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionIEAbiological_process
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0051726Regulation of cell cycleIBAbiological_process
GO:0051898Negative regulation of protein kinase B signalingISSbiological_process
GO:007188914-3-3 protein bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.08792246500.89549902740.62293598921.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0851653821
GSE13712_SHEARDown-0.0403629301
GSE13712_STATICDown-0.0030015301
GSE19018Down-0.0402432277
GSE19899_A1Down-0.1641740800
GSE19899_A2Down-0.0894800588
PubMed_21979375_A1Up1.0014163648
PubMed_21979375_A2Up1.3127227299
GSE35957Down-0.1072605224
GSE36640Up0.2294959288
GSE54402Up0.0382185852
GSE9593Up0.1782202329
GSE43922Down-0.2884896763
GSE24585Up0.3569209001
GSE37065Down-0.1678144052
GSE28863_A1Up0.4625382725
GSE28863_A2Up0.3923052061
GSE28863_A3Up0.2764583021
GSE28863_A4Up0.0224018362
GSE48662Up0.1719281937

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-744-5pMIMAT0004945MIRT037646CLASHFunctional MTI (Weak)23622248
hsa-miR-296-3pMIMAT0004679MIRT038502CLASHFunctional MTI (Weak)23622248
hsa-miR-17-5pMIMAT0000070MIRT050917CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26977878Inhibition of CDK4/6 not only suppresses Rb phosphorylation, but also reduces TSC2 phosphorylation and thus partially attenuates mTORC1 activity
26977878Consequently, dual inhibition of EGFR/HER2 and CDK4/6 invokes a more potent suppression of TSC2 phosphorylation and hence mTORC1/S6K/S6RP activity
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