HCSGD entry for TPH1

1. General information

Official gene symbolTPH1
Entrez ID7166
Gene full nametryptophan hydroxylase 1
Other gene symbolsTPRH TRPH
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004510Tryptophan 5-monooxygenase activityIEAmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0007623Circadian rhythmIEAbiological_process
GO:0009072Aromatic amino acid family metabolic processIEAbiological_process
GO:0016597Amino acid bindingIEAmolecular_function
GO:0016714Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygenIEAmolecular_function
GO:0030279Negative regulation of ossificationIEAbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0035902Response to immobilization stressIEAbiological_process
GO:0042427Serotonin biosynthetic processIEAbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046219Indolalkylamine biosynthetic processTASbiological_process
GO:0046849Bone remodelingIEAbiological_process
GO:0060749Mammary gland alveolus developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.39330824440.84122012460.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1368763986
GSE13712_SHEARUp0.0524022257
GSE13712_STATICUp0.0157566201
GSE19018Down-0.0003435505
GSE19899_A1Down-0.0596604161
GSE19899_A2Down-0.0154305115
PubMed_21979375_A1Down-0.0158359196
PubMed_21979375_A2Down-0.0234438889
GSE35957Up0.1005918040
GSE36640Down-0.1218251984
GSE54402Down-0.0835152897
GSE9593Down-0.1123235974
GSE43922Up0.0170177037
GSE24585Up1.4488812771
GSE37065Down-0.0422018307
GSE28863_A1Up0.0852876994
GSE28863_A2Down-0.0138233157
GSE28863_A3Up0.1297660995
GSE28863_A4Up0.0739721270
GSE48662Down-0.0089765286

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

LX1031DB05199 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.