HCSGD entry for TPH1

1. General information

Official gene symbolTPH1
Entrez ID7166
Gene full nametryptophan hydroxylase 1
Other gene symbolsTPRH TRPH
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004510Tryptophan 5-monooxygenase activityIEAmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0007623Circadian rhythmIEAbiological_process
GO:0009072Aromatic amino acid family metabolic processIEAbiological_process
GO:0016597Amino acid bindingIEAmolecular_function
GO:0016714Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygenIEAmolecular_function
GO:0030279Negative regulation of ossificationIEAbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0035902Response to immobilization stressIEAbiological_process
GO:0042427Serotonin biosynthetic processIEAbiological_process
GO:0043005Neuron projectionIEAcellular_component
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046219Indolalkylamine biosynthetic processTASbiological_process
GO:0046849Bone remodelingIEAbiological_process
GO:0060749Mammary gland alveolus developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.39330824440.84122012460.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1368763986
GSE13712_SHEARUp0.0524022257
GSE13712_STATICUp0.0157566201
GSE19018Down-0.0003435505
GSE19899_A1Down-0.0596604161
GSE19899_A2Down-0.0154305115
PubMed_21979375_A1Down-0.0158359196
PubMed_21979375_A2Down-0.0234438889
GSE35957Up0.1005918040
GSE36640Down-0.1218251984
GSE54402Down-0.0835152897
GSE9593Down-0.1123235974
GSE43922Up0.0170177037
GSE24585Up1.4488812771
GSE37065Down-0.0422018307
GSE28863_A1Up0.0852876994
GSE28863_A2Down-0.0138233157
GSE28863_A3Up0.1297660995
GSE28863_A4Up0.0739721270
GSE48662Down-0.0089765286

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

LX1031DB05199 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.