HCSGD entry for NKX2-1

1. General information

Official gene symbolNKX2-1
Entrez ID7080
Gene full nameNK2 homeobox 1
Other gene symbolsBCH BHC NK-2 NKX2.1 NKX2A TEBP TITF1 TTF-1 TTF1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001764Neuron migrationIEAbiological_process
GO:0003677DNA bindingIMPmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmISScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0006644Phospholipid metabolic processIEAbiological_process
GO:0007411Axon guidanceIEAbiological_process
GO:0007420Brain developmentIMPbiological_process
GO:0007492Endoderm developmentIEAbiological_process
GO:0007626Locomotory behaviorIEAbiological_process
GO:0009725Response to hormoneIEPbiological_process
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0010719Negative regulation of epithelial to mesenchymal transitionIDAbiological_process
GO:0021759Globus pallidus developmentIMPbiological_process
GO:0021766Hippocampus developmentIEAbiological_process
GO:0021795Cerebral cortex cell migrationIEAbiological_process
GO:0021798Forebrain dorsal/ventral pattern formationIEAbiological_process
GO:0021877Forebrain neuron fate commitmentIEAbiological_process
GO:0021892Cerebral cortex GABAergic interneuron differentiationIEAbiological_process
GO:0021983Pituitary gland developmentIEAbiological_process
GO:0030324Lung developmentIEPbiological_process
GO:0030336Negative regulation of cell migrationIDAbiological_process
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayIDAbiological_process
GO:0030878Thyroid gland developmentIEP IMPbiological_process
GO:0030900Forebrain developmentIEPbiological_process
GO:0031128Developmental inductionIEAbiological_process
GO:0033327Leydig cell differentiationIEAbiological_process
GO:0042696MenarcheIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIDA ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048646Anatomical structure formation involved in morphogenesisIEAbiological_process
GO:0048709Oligodendrocyte differentiationIEAbiological_process
GO:0060430Lung saccule developmentIEAbiological_process
GO:0060441Epithelial tube branching involved in lung morphogenesisIEPbiological_process
GO:0060486Clara cell differentiationIEAbiological_process
GO:0060510Type II pneumocyte differentiationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.68638463200.93321206640.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0607376695
GSE13712_SHEARDown-0.0115109273
GSE13712_STATICUp0.0626604891
GSE19018Up0.0865065496
GSE19899_A1Up0.0190804160
GSE19899_A2Up0.0930957114
PubMed_21979375_A1Down-0.0471575672
PubMed_21979375_A2Up0.1140452467
GSE35957Up0.0707278640
GSE36640Up0.0375730199
GSE54402Up0.0177502871
GSE9593Up0.0315993652
GSE43922Up0.0482307299
GSE24585Up0.1955365877
GSE37065Down-0.0459192013
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.0731488968

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7f-5pMIMAT0000067MIRT032087qRT-PCRFunctional MTI (Weak)19956384
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24488586The transcription factors predicted to regulate these changes, Nf-kappaB, Myb, Nkx2-1, Nr5a2, and Ep300, are known to regulate inflammation, differentiation, lipid metabolism, and chromatin remodeling, all of which have previously been implicated in aging
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