HCSGD entry for NKX2-1

1. General information

Official gene symbolNKX2-1
Entrez ID7080
Gene full nameNK2 homeobox 1
Other gene symbolsBCH BHC NK-2 NKX2.1 NKX2A TEBP TITF1 TTF-1 TTF1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0001764Neuron migrationIEAbiological_process
GO:0003677DNA bindingIMPmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmISScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0006644Phospholipid metabolic processIEAbiological_process
GO:0007411Axon guidanceIEAbiological_process
GO:0007420Brain developmentIMPbiological_process
GO:0007492Endoderm developmentIEAbiological_process
GO:0007626Locomotory behaviorIEAbiological_process
GO:0009725Response to hormoneIEPbiological_process
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0010719Negative regulation of epithelial to mesenchymal transitionIDAbiological_process
GO:0021759Globus pallidus developmentIMPbiological_process
GO:0021766Hippocampus developmentIEAbiological_process
GO:0021795Cerebral cortex cell migrationIEAbiological_process
GO:0021798Forebrain dorsal/ventral pattern formationIEAbiological_process
GO:0021877Forebrain neuron fate commitmentIEAbiological_process
GO:0021892Cerebral cortex GABAergic interneuron differentiationIEAbiological_process
GO:0021983Pituitary gland developmentIEAbiological_process
GO:0030324Lung developmentIEPbiological_process
GO:0030336Negative regulation of cell migrationIDAbiological_process
GO:0030512Negative regulation of transforming growth factor beta receptor signaling pathwayIDAbiological_process
GO:0030878Thyroid gland developmentIEP IMPbiological_process
GO:0030900Forebrain developmentIEPbiological_process
GO:0031128Developmental inductionIEAbiological_process
GO:0033327Leydig cell differentiationIEAbiological_process
GO:0042696MenarcheIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIDA ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0048646Anatomical structure formation involved in morphogenesisIEAbiological_process
GO:0048709Oligodendrocyte differentiationIEAbiological_process
GO:0060430Lung saccule developmentIEAbiological_process
GO:0060441Epithelial tube branching involved in lung morphogenesisIEPbiological_process
GO:0060486Clara cell differentiationIEAbiological_process
GO:0060510Type II pneumocyte differentiationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.68638463200.93321206640.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0607376695
GSE13712_SHEARDown-0.0115109273
GSE13712_STATICUp0.0626604891
GSE19018Up0.0865065496
GSE19899_A1Up0.0190804160
GSE19899_A2Up0.0930957114
PubMed_21979375_A1Down-0.0471575672
PubMed_21979375_A2Up0.1140452467
GSE35957Up0.0707278640
GSE36640Up0.0375730199
GSE54402Up0.0177502871
GSE9593Up0.0315993652
GSE43922Up0.0482307299
GSE24585Up0.1955365877
GSE37065Down-0.0459192013
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.0731488968

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7f-5pMIMAT0000067MIRT032087qRT-PCRFunctional MTI (Weak)19956384
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24488586The transcription factors predicted to regulate these changes, Nf-kappaB, Myb, Nkx2-1, Nr5a2, and Ep300, are known to regulate inflammation, differentiation, lipid metabolism, and chromatin remodeling, all of which have previously been implicated in aging
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