HCSGD entry for TIAM1


1. General information

Official gene symbolTIAM1
Entrez ID7074
Gene full nameT-cell lymphoma invasion and metastasis 1
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005057Receptor signaling protein activityIEAmolecular_function
GO:0005085Guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEA TASmolecular_function
GO:0005543Phospholipid bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0005911Cell-cell junctionIDAcellular_component
GO:0007160Cell-matrix adhesionIMPbiological_process
GO:0007264Small GTPase mediated signal transductionIEA TASbiological_process
GO:0016477Cell migrationIMPbiological_process
GO:0016601Rac protein signal transductionIMPbiological_process
GO:0030676Rac guanyl-nucleotide exchange factor activityIMPmolecular_function
GO:0031234Extrinsic component of cytoplasmic side of plasma membraneIDAcellular_component
GO:0032314Regulation of Rac GTPase activityIMPbiological_process
GO:0032318Regulation of Ras GTPase activityIMP TASbiological_process
GO:0032319Regulation of Rho GTPase activityIMP TASbiological_process
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043087Regulation of GTPase activityIMP TASbiological_process
GO:0044291Cell-cell contact zoneIDAcellular_component
GO:0046875Ephrin receptor bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048013Ephrin receptor signaling pathwayIEAbiological_process
GO:0050772Positive regulation of axonogenesisIEAbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06238253490.89266876640.53988373321.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1188083082
GSE13712_SHEARUp0.0126874696
GSE13712_STATICUp0.0810497312
GSE19018Up0.0785942256
GSE19899_A1Up0.2605548473
GSE19899_A2Up0.2382734880
PubMed_21979375_A1Up0.6525039210
PubMed_21979375_A2Up0.4824483848
GSE35957Down-0.9735729458
GSE36640Up0.2731425615
GSE54402Up0.0731810669
GSE9593Up0.0235511759
GSE43922Up0.3277831851
GSE24585Up0.0921494425
GSE37065Down-0.5633080606
GSE28863_A1Up0.3759832045
GSE28863_A2Down-0.0559443646
GSE28863_A3Up0.4471880822
GSE28863_A4Up0.1450272159
GSE48662Down-0.0921710682

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT005565Luciferase reporter assay//Microarray//Northern blot//qRT-PCRFunctional MTI20826792
hsa-miR-21-5pMIMAT0000076MIRT005565Luciferase reporter assayFunctional MTI23442323
hsa-miR-31-5pMIMAT0000089MIRT005566Luciferase reporter assay//Microarray//Northern blot//qRT-PCRFunctional MTI20826792
hsa-miR-335-5pMIMAT0000765MIRT018498MicroarrayFunctional MTI (Weak)18185580
hsa-miR-744-5pMIMAT0004945MIRT037502CLASHFunctional MTI (Weak)23622248
hsa-miR-93-3pMIMAT0004509MIRT038766CLASHFunctional MTI (Weak)23622248
hsa-miR-769-3pMIMAT0003887MIRT039107CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040238CLASHFunctional MTI (Weak)23622248
hsa-miR-221-3pMIMAT0000278MIRT046873CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT052155CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22302986We have shown that fibroblasts deficient in the Rac exchange factor Tiam1 promote invasion and metastasis of associated epithelial tumor cells
22302986We find that stress-induced senescence induces decreased fibroblast Tiam1 protein levels and increased osteopontin levels, and that senescent fibroblast lysates induce Tiam1 protein degradation in a calcium- and calpain-dependent fashion
22302986Changes in fibroblast Tiam1 protein levels induce converse changes in osteopontin mRNA and protein
22302986These effects in epithelial cells are ameliorated by either increasing fibroblast Tiam1 or decreasing fibroblast osteopontin
22302986These findings indicate that one mechanism by which senescent fibroblasts promote neoplastic progression in associated tumors is through degradation of fibroblast Tiam1 protein and the consequent increase in secretion of osteopontin by fibroblasts
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