HCSGD entry for TIAM1
1. General information
| Official gene symbol | TIAM1 |
|---|---|
| Entrez ID | 7074 |
| Gene full name | T-cell lymphoma invasion and metastasis 1 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005057 | Receptor signaling protein activity | IEA | molecular_function |
| GO:0005085 | Guanyl-nucleotide exchange factor activity | IEA | molecular_function |
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity | IEA TAS | molecular_function |
| GO:0005543 | Phospholipid binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0005911 | Cell-cell junction | IDA | cellular_component |
| GO:0007160 | Cell-matrix adhesion | IMP | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | IEA TAS | biological_process |
| GO:0016477 | Cell migration | IMP | biological_process |
| GO:0016601 | Rac protein signal transduction | IMP | biological_process |
| GO:0030676 | Rac guanyl-nucleotide exchange factor activity | IMP | molecular_function |
| GO:0031234 | Extrinsic component of cytoplasmic side of plasma membrane | IDA | cellular_component |
| GO:0032314 | Regulation of Rac GTPase activity | IMP | biological_process |
| GO:0032318 | Regulation of Ras GTPase activity | IMP TAS | biological_process |
| GO:0032319 | Regulation of Rho GTPase activity | IMP TAS | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | TAS | biological_process |
| GO:0043087 | Regulation of GTPase activity | IMP TAS | biological_process |
| GO:0044291 | Cell-cell contact zone | IDA | cellular_component |
| GO:0046875 | Ephrin receptor binding | IEA | molecular_function |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048013 | Ephrin receptor signaling pathway | IEA | biological_process |
| GO:0050772 | Positive regulation of axonogenesis | IEA | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | TAS | biological_process |
| GO:0097190 | Apoptotic signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0623825349 | 0.8926687664 | 0.5398837332 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1188083082 |
| GSE13712_SHEAR | Up | 0.0126874696 |
| GSE13712_STATIC | Up | 0.0810497312 |
| GSE19018 | Up | 0.0785942256 |
| GSE19899_A1 | Up | 0.2605548473 |
| GSE19899_A2 | Up | 0.2382734880 |
| PubMed_21979375_A1 | Up | 0.6525039210 |
| PubMed_21979375_A2 | Up | 0.4824483848 |
| GSE35957 | Down | -0.9735729458 |
| GSE36640 | Up | 0.2731425615 |
| GSE54402 | Up | 0.0731810669 |
| GSE9593 | Up | 0.0235511759 |
| GSE43922 | Up | 0.3277831851 |
| GSE24585 | Up | 0.0921494425 |
| GSE37065 | Down | -0.5633080606 |
| GSE28863_A1 | Up | 0.3759832045 |
| GSE28863_A2 | Down | -0.0559443646 |
| GSE28863_A3 | Up | 0.4471880822 |
| GSE28863_A4 | Up | 0.1450272159 |
| GSE48662 | Down | -0.0921710682 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT005565 | Luciferase reporter assay//Microarray//Northern blot//qRT-PCR | Functional MTI | 20826792 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT005565 | Luciferase reporter assay | Functional MTI | 23442323 |
| hsa-miR-31-5p | MIMAT0000089 | MIRT005566 | Luciferase reporter assay//Microarray//Northern blot//qRT-PCR | Functional MTI | 20826792 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018498 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037502 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-3p | MIMAT0004509 | MIRT038766 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-3p | MIMAT0003887 | MIRT039107 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040238 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT046873 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052155 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22302986 | We have shown that fibroblasts deficient in the Rac exchange factor Tiam1 promote invasion and metastasis of associated epithelial tumor cells |
| 22302986 | We find that stress-induced senescence induces decreased fibroblast Tiam1 protein levels and increased osteopontin levels, and that senescent fibroblast lysates induce Tiam1 protein degradation in a calcium- and calpain-dependent fashion |
| 22302986 | Changes in fibroblast Tiam1 protein levels induce converse changes in osteopontin mRNA and protein |
| 22302986 | These effects in epithelial cells are ameliorated by either increasing fibroblast Tiam1 or decreasing fibroblast osteopontin |
| 22302986 | These findings indicate that one mechanism by which senescent fibroblasts promote neoplastic progression in associated tumors is through degradation of fibroblast Tiam1 protein and the consequent increase in secretion of osteopontin by fibroblasts |
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