HCSGD entry for THRA


1. General information

Official gene symbolTHRA
Entrez ID7067
Gene full namethyroid hormone receptor, alpha
Other gene symbolsAR7 CHNG6 EAR7 ERB-T-1 ERBA ERBA1 NR1A1 THRA1 THRA2 c-ERBA-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001502Cartilage condensationIEAbiological_process
GO:0001503OssificationIEAbiological_process
GO:0002153Steroid receptor RNA activator RNA bindingIEAmolecular_function
GO:0002155Regulation of thyroid hormone mediated signaling pathwayIEAbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0004879Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityIEAmolecular_function
GO:0004887Thyroid hormone receptor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005829CytosolIDAcellular_component
GO:0006357Regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007611Learning or memoryIEAbiological_process
GO:0008016Regulation of heart contractionIEAbiological_process
GO:0008050Female courtship behaviorIEAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0009409Response to coldIEAbiological_process
GO:0009755Hormone-mediated signaling pathwayIDAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010831Positive regulation of myotube differentiationIEAbiological_process
GO:0017025TBP-class protein bindingIDAmolecular_function
GO:0017055Negative regulation of RNA polymerase II transcriptional preinitiation complex assemblyIDAbiological_process
GO:0019904Protein domain specific bindingIPImolecular_function
GO:0030218Erythrocyte differentiationIEAbiological_process
GO:0030878Thyroid gland developmentIEAbiological_process
GO:0031490Chromatin DNA bindingIEAmolecular_function
GO:0032403Protein complex bindingIEAmolecular_function
GO:0033032Regulation of myeloid cell apoptotic processIEAbiological_process
GO:0042994Cytoplasmic sequestering of transcription factorIEAbiological_process
GO:0043565Sequence-specific DNA bindingIEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045892Negative regulation of transcription, DNA-templatedIDA IEAbiological_process
GO:0045925Positive regulation of female receptivityIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0050994Regulation of lipid catabolic processIEAbiological_process
GO:0060509Type I pneumocyte differentiationIEAbiological_process
GO:0070324Thyroid hormone bindingIDA IPImolecular_function
GO:2000143Negative regulation of DNA-templated transcription, initiationIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95560833550.03116219750.99999024730.3313753331

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1037249627
GSE13712_SHEARDown-0.6548308614
GSE13712_STATICDown-0.3946664781
GSE19018Up0.1163549171
GSE19899_A1Down-0.0873093478
GSE19899_A2Down-0.1614042394
PubMed_21979375_A1Down-0.5000811107
PubMed_21979375_A2Down-0.1498718266
GSE35957Up0.0551410951
GSE36640Up0.0618679753
GSE54402Down-0.4385329112
GSE9593Up0.0651907826
GSE43922Down-1.0065519366
GSE24585Down-0.5925513703
GSE37065Down-0.2948759815
GSE28863_A1Up0.1407090844
GSE28863_A2Up0.2069404756
GSE28863_A3Down-0.1145043120
GSE28863_A4Down-0.2161244876
GSE48662Up0.6787633371

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL264410CHEMBL18609P10827
CHEMBL196642CHEMBL18609P10827
CHEMBL250104CHEMBL18609P10827
CHEMBL193851CHEMBL18609P10827
CHEMBL263630CHEMBL18609P10827
CHEMBL250513CHEMBL18609P10827
CHEMBL264527CHEMBL18609P10827
CHEMBL236498CHEMBL18609P10827
CHEMBL250308CHEMBL18609P10827
CHEMBL457529CHEMBL18609P10827
CHEMBL519215CHEMBL18609P10827
CHEMBL98135CHEMBL18609P10827
CHEMBL264410CHEMBL18609P10827
CHEMBL458784CHEMBL18609P10827
CHEMBL519721CHEMBL18609P10827
CHEMBL486158CHEMBL18609P10827
CHEMBL111953CHEMBL18609P10827
CHEMBL1544CHEMBL18609P10827
CHEMBL407819CHEMBL18609P10827
CHEMBL263631CHEMBL18609P10827
CHEMBL402714CHEMBL18609P10827
CHEMBL198367CHEMBL18609P10827
CHEMBL236290CHEMBL18609P10827
CHEMBL516330CHEMBL18609P10827
CHEMBL107400CHEMBL18609P10827
CHEMBL485939CHEMBL18609P10827
CHEMBL391512CHEMBL18609P10827
CHEMBL196613CHEMBL18609P10827
CHEMBL195079CHEMBL18609P10827
CHEMBL264152CHEMBL18609P10827
CHEMBL250103CHEMBL18609P10827
CHEMBL97187CHEMBL18609P10827
CHEMBL193615CHEMBL18609P10827
CHEMBL109279CHEMBL18609P10827
CHEMBL97613CHEMBL18609P10827
CHEMBL236289CHEMBL18609P10827
CHEMBL1544CHEMBL18609P10827
CHEMBL258886CHEMBL18609P10827
CHEMBL391513CHEMBL18609P10827
CHEMBL1544CHEMBL18609P10827
CHEMBL372428CHEMBL18609P10827
CHEMBL1544CHEMBL18609P10827
CHEMBL486358CHEMBL18609P10827
CHEMBL264152CHEMBL18609P10827
CHEMBL195327CHEMBL18609P10827
CHEMBL447378CHEMBL18609P10827
CHEMBL236500CHEMBL18609P10827
CHEMBL264153CHEMBL18609P10827
CHEMBL249895CHEMBL18609P10827
CHEMBL264152CHEMBL18609P10827
CHEMBL259096CHEMBL18609P10827
CHEMBL457527CHEMBL18609P10827
CHEMBL259096CHEMBL18609P10827
CHEMBL520857CHEMBL18609P10827
CHEMBL198875CHEMBL18609P10827
CHEMBL260482CHEMBL18609P10827
CHEMBL193864CHEMBL18609P10827
CHEMBL258886CHEMBL18609P10827
CHEMBL39174CHEMBL18609P10827
CHEMBL485927CHEMBL18609P10827
CHEMBL110158CHEMBL18609P10827
CHEMBL109430CHEMBL18609P10827
CHEMBL263631CHEMBL18609P10827
CHEMBL457528CHEMBL18609P10827
CHEMBL1544CHEMBL18609P10827
CHEMBL250101CHEMBL18609P10827
CHEMBL411185CHEMBL18609P10827
CHEMBL486359CHEMBL18609P10827
CHEMBL41036CHEMBL18609P10827
CHEMBL485758CHEMBL18609P10827
CHEMBL1544CHEMBL18609P10827
CHEMBL440975CHEMBL18609P10827
CHEMBL264410CHEMBL18609P10827
CHEMBL318132CHEMBL18609P10827
CHEMBL448595CHEMBL18609P10827
CHEMBL249897CHEMBL18609P10827
CHEMBL107400CHEMBL18609P10827
CHEMBL41036CHEMBL18609P10827
CHEMBL46882CHEMBL18609P10827
CHEMBL364368CHEMBL18609P10827
CHEMBL263630CHEMBL18609P10827
CHEMBL194242CHEMBL18609P10827
CHEMBL263631CHEMBL18609P10827
CHEMBL260482CHEMBL18609P10827
CHEMBL236080CHEMBL18609P10827
CHEMBL436859CHEMBL18609P10827
CHEMBL250307CHEMBL18609P10827
CHEMBL1544CHEMBL18609P10827
CHEMBL264153CHEMBL18609P10827
CHEMBL258886CHEMBL18609P10827
CHEMBL236499CHEMBL18609P10827
CHEMBL512383CHEMBL18609P10827
CHEMBL471488CHEMBL18609P10827
CHEMBL112087CHEMBL18609P10827
CHEMBL500875CHEMBL18609P10827
CHEMBL505084CHEMBL18609P10827
CHEMBL427568CHEMBL18609P10827
CHEMBL402713CHEMBL18609P10827
CHEMBL459148CHEMBL18609P10827
CHEMBL236291CHEMBL18609P10827
CHEMBL260482CHEMBL18609P10827
CHEMBL112087CHEMBL18609P10827
CHEMBL391367CHEMBL18609P10827
CHEMBL109279CHEMBL18609P10827
CHEMBL1544CHEMBL18609P10827
CHEMBL259096CHEMBL18609P10827
CHEMBL371245CHEMBL18609P10827
CHEMBL511862CHEMBL18609P10827
CHEMBL264153CHEMBL18609P10827
CHEMBL41036CHEMBL18609P10827
CHEMBL393201CHEMBL18609P10827
CHEMBL250104CHEMBL18609P10827
CHEMBL485928CHEMBL18609P10827
CHEMBL263630CHEMBL18609P10827
CHEMBL394678CHEMBL18609P10827
CHEMBL237601CHEMBL18609P10827
CHEMBL237241CHEMBL18609P10827
CHEMBL237605CHEMBL18609P10827
CHEMBL236131CHEMBL18609P10827
CHEMBL396873CHEMBL18609P10827
CHEMBL237035CHEMBL18609P10827
CHEMBL396086CHEMBL18609P10827
CHEMBL192427CHEMBL18609P10827
CHEMBL235491CHEMBL18609P10827
CHEMBL235922CHEMBL18609P10827
CHEMBL236033CHEMBL18609P10827
CHEMBL237456CHEMBL18609P10827
CHEMBL235252CHEMBL18609P10827
CHEMBL396089CHEMBL18609P10827
CHEMBL235904CHEMBL18609P10827
CHEMBL425366CHEMBL18609P10827
CHEMBL237823CHEMBL18609P10827
CHEMBL236133CHEMBL18609P10827
CHEMBL236543CHEMBL18609P10827
CHEMBL236132CHEMBL18609P10827
CHEMBL236338CHEMBL18609P10827
CHEMBL195556CHEMBL18609P10827
CHEMBL398106CHEMBL18609P10827
CHEMBL237600CHEMBL18609P10827
CHEMBL395602CHEMBL18609P10827
CHEMBL237600CHEMBL18609P10827
CHEMBL192142CHEMBL18609P10827
CHEMBL236134CHEMBL18609P10827
CHEMBL428375CHEMBL18609P10827
CHEMBL235113CHEMBL18609P10827
CHEMBL236339CHEMBL18609P10827
CHEMBL157885CHEMBL18609P10827
CHEMBL192639CHEMBL18609P10827
CHEMBL394913CHEMBL18609P10827
CHEMBL193198CHEMBL18609P10827
CHEMBL237611CHEMBL18609P10827
CHEMBL418432CHEMBL18608P10827
CHEMBL291053CHEMBL18608P10827
CHEMBL1544CHEMBL18608P10827
CHEMBL1544CHEMBL18608P10827
CHEMBL471488CHEMBL18608P10827
CHEMBL40738CHEMBL18608P10827
CHEMBL41632CHEMBL18608P10827
CHEMBL110335CHEMBL18608P10827
CHEMBL107400CHEMBL18608P10827
CHEMBL41036CHEMBL18608P10827
CHEMBL594025CHEMBL18608P10827
CHEMBL105983CHEMBL18608P10827
CHEMBL418432CHEMBL18608P10827
CHEMBL594047CHEMBL18608P10827
CHEMBL39174CHEMBL18608P10827
CHEMBL596350CHEMBL18608P10827
CHEMBL419016CHEMBL18608P10827
CHEMBL124205CHEMBL18608P10827
CHEMBL289965CHEMBL18608P10827
CHEMBL41036CHEMBL18608P10827
CHEMBL40738CHEMBL18608P10827
CHEMBL289343CHEMBL18608P10827
CHEMBL41036CHEMBL18608P10827
CHEMBL594024CHEMBL18608P10827
CHEMBL41314CHEMBL18608P10827
CHEMBL1544CHEMBL18608P10827
CHEMBL125242CHEMBL18608P10827
CHEMBL107400CHEMBL18608P10827
CHEMBL557CHEMBL18608P10827
CHEMBL39174CHEMBL18608P10827
CHEMBL322361CHEMBL18608P10827
CHEMBL1544CHEMBL18608P10827
CHEMBL608990CHEMBL18608P10827
CHEMBL551184CHEMBL18608P10827
CHEMBL83829CHEMBL18608P10827
CHEMBL560911CHEMBL18608P10827
CHEMBL558889CHEMBL18608P10827
CHEMBL552158CHEMBL18608P10827
CHEMBL558107CHEMBL18608P10827
CHEMBL551450CHEMBL18608P10827
CHEMBL82131CHEMBL18608P10827
CHEMBL471897CHEMBL18608P10827
CHEMBL549557CHEMBL18608P10827
CHEMBL551710CHEMBL18608P10827
CHEMBL85322CHEMBL18608P10827
CHEMBL83953CHEMBL18608P10827
CHEMBL551979CHEMBL18608P10827
CHEMBL538150CHEMBL18608P10827
CHEMBL562250CHEMBL18608P10827
CHEMBL555726CHEMBL18608P10827
CHEMBL560114CHEMBL18608P10827
CHEMBL560510CHEMBL18608P10827
CHEMBL539139CHEMBL18608P10827
CHEMBL551185CHEMBL18608P10827
CHEMBL550845CHEMBL18608P10827
CHEMBL550094CHEMBL18608P10827
CHEMBL157885CHEMBL18608P10827
CHEMBL553652CHEMBL18608P10827
CHEMBL559520CHEMBL18608P10827
CHEMBL560172CHEMBL18608P10827
CHEMBL549483CHEMBL18608P10827
CHEMBL539393CHEMBL18608P10827
CHEMBL557905CHEMBL18608P10827
CHEMBL552392CHEMBL18608P10827
CHEMBL552185CHEMBL18608P10827
CHEMBL160883CHEMBL18608P10827
CHEMBL560311CHEMBL18608P10827
CHEMBL565150CHEMBL18608P10827
CHEMBL552105CHEMBL18608P10827
CHEMBL125946CHEMBL18608P10827
CHEMBL558106CHEMBL18608P10827
CHEMBL633CHEMBL18608P10827
CHEMBL561245CHEMBL18608P10827
CHEMBL121893CHEMBL18608P10827
CHEMBL560512CHEMBL18608P10827
CHEMBL572348CHEMBL18608P10827
CHEMBL160703CHEMBL18608P10827
CHEMBL563368CHEMBL18608P10827
CHEMBL86271CHEMBL18608P10827
CHEMBL555749CHEMBL18608P10827
CHEMBL551791CHEMBL18608P10827
CHEMBL553190CHEMBL18608P10827
CHEMBL561050CHEMBL18608P10827
CHEMBL561648CHEMBL18608P10827
CHEMBL549685CHEMBL18608P10827
CHEMBL563181CHEMBL18608P10827
CHEMBL559716CHEMBL18608P10827
CHEMBL549482CHEMBL18608P10827
CHEMBL560972CHEMBL18608P10827
CHEMBL561850CHEMBL18608P10827
CHEMBL552106CHEMBL18608P10827
CHEMBL203777CHEMBL18607P10827
CHEMBL378593CHEMBL18607P10827
CHEMBL251439CHEMBL18607P10827
CHEMBL557CHEMBL18607P10827
CHEMBL203555CHEMBL18607P10827
CHEMBL203828CHEMBL18607P10827
CHEMBL202521CHEMBL18607P10827
CHEMBL250880CHEMBL18607P10827
CHEMBL425939CHEMBL18607P10827
CHEMBL193198CHEMBL18607P10827
CHEMBL217298CHEMBL18607P10827
CHEMBL202336CHEMBL18607P10827
CHEMBL217221CHEMBL18607P10827
CHEMBL205171CHEMBL18607P10827
CHEMBL381937CHEMBL18607P10827
CHEMBL202940CHEMBL18607P10827
CHEMBL204609CHEMBL18607P10827
CHEMBL192490CHEMBL18607P10827
CHEMBL192427CHEMBL18607P10827
CHEMBL425366CHEMBL18607P10827
CHEMBL192639CHEMBL18607P10827
CHEMBL193198CHEMBL18607P10827
CHEMBL193152CHEMBL18607P10827
CHEMBL192142CHEMBL18607P10827
CHEMBL195855CHEMBL18607P10827
CHEMBL192426CHEMBL18607P10827
CHEMBL195556CHEMBL18607P10827
CHEMBL157885CHEMBL18607P10827
CHEMBL192508CHEMBL18607P10827
CHEMBL425557CHEMBL18607P10827
CHEMBL193198CHEMBL18604P10827
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  • Drugs

Name

Drug

Accession number

DextrothyroxineDB00509 APRD00911
LiotrixDB01583 -
3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic AcidDB03176 EXPT01852
KB2115DB05035 -
NRP409DB05235 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-18a-5pMIMAT0000072MIRT004386Microarray//Northern blotFunctional MTI (Weak)16331254
hsa-miR-375MIMAT0000728MIRT019902MicroarrayFunctional MTI (Weak)20215506
hsa-miR-877-5pMIMAT0004949MIRT037281CLASHFunctional MTI (Weak)23622248
hsa-miR-330-3pMIMAT0000751MIRT043845CLASHFunctional MTI (Weak)23622248
hsa-miR-15b-5pMIMAT0000417MIRT046501CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.