HCSGD entry for THRA
1. General information
| Official gene symbol | THRA |
|---|---|
| Entrez ID | 7067 |
| Gene full name | thyroid hormone receptor, alpha |
| Other gene symbols | AR7 CHNG6 EAR7 ERB-T-1 ERBA ERBA1 NR1A1 THRA1 THRA2 c-ERBA-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001502 | Cartilage condensation | IEA | biological_process |
| GO:0001503 | Ossification | IEA | biological_process |
| GO:0002153 | Steroid receptor RNA activator RNA binding | IEA | molecular_function |
| GO:0002155 | Regulation of thyroid hormone mediated signaling pathway | IEA | biological_process |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA | molecular_function |
| GO:0003707 | Steroid hormone receptor activity | IEA | molecular_function |
| GO:0004879 | Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | IEA | molecular_function |
| GO:0004887 | Thyroid hormone receptor activity | IDA IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | IDA | cellular_component |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0007611 | Learning or memory | IEA | biological_process |
| GO:0008016 | Regulation of heart contraction | IEA | biological_process |
| GO:0008050 | Female courtship behavior | IEA | biological_process |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0009409 | Response to cold | IEA | biological_process |
| GO:0009755 | Hormone-mediated signaling pathway | IDA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010831 | Positive regulation of myotube differentiation | IEA | biological_process |
| GO:0017025 | TBP-class protein binding | IDA | molecular_function |
| GO:0017055 | Negative regulation of RNA polymerase II transcriptional preinitiation complex assembly | IDA | biological_process |
| GO:0019904 | Protein domain specific binding | IPI | molecular_function |
| GO:0030218 | Erythrocyte differentiation | IEA | biological_process |
| GO:0030878 | Thyroid gland development | IEA | biological_process |
| GO:0031490 | Chromatin DNA binding | IEA | molecular_function |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0033032 | Regulation of myeloid cell apoptotic process | IEA | biological_process |
| GO:0042994 | Cytoplasmic sequestering of transcription factor | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0044212 | Transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA IEA | biological_process |
| GO:0045925 | Positive regulation of female receptivity | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0050994 | Regulation of lipid catabolic process | IEA | biological_process |
| GO:0060509 | Type I pneumocyte differentiation | IEA | biological_process |
| GO:0070324 | Thyroid hormone binding | IDA IPI | molecular_function |
| GO:2000143 | Negative regulation of DNA-templated transcription, initiation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9556083355 | 0.0311621975 | 0.9999902473 | 0.3313753331 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1037249627 |
| GSE13712_SHEAR | Down | -0.6548308614 |
| GSE13712_STATIC | Down | -0.3946664781 |
| GSE19018 | Up | 0.1163549171 |
| GSE19899_A1 | Down | -0.0873093478 |
| GSE19899_A2 | Down | -0.1614042394 |
| PubMed_21979375_A1 | Down | -0.5000811107 |
| PubMed_21979375_A2 | Down | -0.1498718266 |
| GSE35957 | Up | 0.0551410951 |
| GSE36640 | Up | 0.0618679753 |
| GSE54402 | Down | -0.4385329112 |
| GSE9593 | Up | 0.0651907826 |
| GSE43922 | Down | -1.0065519366 |
| GSE24585 | Down | -0.5925513703 |
| GSE37065 | Down | -0.2948759815 |
| GSE28863_A1 | Up | 0.1407090844 |
| GSE28863_A2 | Up | 0.2069404756 |
| GSE28863_A3 | Down | -0.1145043120 |
| GSE28863_A4 | Down | -0.2161244876 |
| GSE48662 | Up | 0.6787633371 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Dextrothyroxine | DB00509 | APRD00911 |
| Liotrix | DB01583 | - |
| 3,5-Dichloro-4-[(4-Hydroxy-3-Isopropylphenoxy)Phenylacetic Acid | DB03176 | EXPT01852 |
| KB2115 | DB05035 | - |
| NRP409 | DB05235 | - |
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-18a-5p | MIMAT0000072 | MIRT004386 | Microarray//Northern blot | Functional MTI (Weak) | 16331254 |
| hsa-miR-375 | MIMAT0000728 | MIRT019902 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-877-5p | MIMAT0004949 | MIRT037281 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-330-3p | MIMAT0000751 | MIRT043845 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046501 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
