HCSGD entry for TERF2
1. General information
| Official gene symbol | TERF2 |
|---|---|
| Entrez ID | 7014 |
| Gene full name | telomeric repeat binding factor 2 |
| Other gene symbols | TRBF2 TRF2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000723 | Telomere maintenance | IMP TAS | biological_process |
| GO:0000781 | Chromosome, telomeric region | IDA | cellular_component |
| GO:0000783 | Nuclear telomere cap complex | IDA | cellular_component |
| GO:0001309 | Age-dependent telomere shortening | NAS | biological_process |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003691 | Double-stranded telomeric DNA binding | ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0007004 | Telomere maintenance via telomerase | IC | biological_process |
| GO:0007049 | Cell cycle | IEA | biological_process |
| GO:0008022 | Protein C-terminus binding | IPI | molecular_function |
| GO:0010834 | Telomere maintenance via telomere shortening | IMP | biological_process |
| GO:0016233 | Telomere capping | IMP | biological_process |
| GO:0030870 | Mre11 complex | IDA | cellular_component |
| GO:0031627 | Telomeric loop formation | IDA | biological_process |
| GO:0031848 | Protection from non-homologous end joining at telomere | IMP | biological_process |
| GO:0032205 | Negative regulation of telomere maintenance | IDA | biological_process |
| GO:0032214 | Negative regulation of telomere maintenance via semi-conservative replication | NAS | biological_process |
| GO:0042162 | Telomeric DNA binding | IDA IEA | molecular_function |
| GO:0042803 | Protein homodimerization activity | IEA IPI | molecular_function |
| GO:0070198 | Protein localization to chromosome, telomeric region | IMP | biological_process |
| GO:0090398 | Cellular senescence | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2254943923 | 0.9261801413 | 0.9068369901 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0923195408 |
| GSE13712_SHEAR | Up | 0.1753528435 |
| GSE13712_STATIC | Up | 0.0457202206 |
| GSE19018 | Down | -0.0548010318 |
| GSE19899_A1 | Up | 0.1350652943 |
| GSE19899_A2 | Up | 0.7831775685 |
| PubMed_21979375_A1 | Up | 0.7063390594 |
| PubMed_21979375_A2 | Up | 0.4785409195 |
| GSE35957 | Down | -0.0292710303 |
| GSE36640 | Down | -0.0652715214 |
| GSE54402 | Up | 0.3282946536 |
| GSE9593 | Down | -0.1569677731 |
| GSE43922 | Up | 0.0380229708 |
| GSE24585 | Up | 0.1185678700 |
| GSE37065 | Up | 0.0107449571 |
| GSE28863_A1 | Down | -0.2485435980 |
| GSE28863_A2 | Up | 0.0978930923 |
| GSE28863_A3 | Down | -0.0817298350 |
| GSE28863_A4 | Up | 0.0692915579 |
| GSE48662 | Down | -0.2384233592 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT023208 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030265 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-766-3p | MIMAT0003888 | MIRT039036 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046463 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT048736 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049699 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25840590 | When telomere dysfunction was induced in adult AEC2s by conditional deletion of the shelterin component telomeric repeat-binding factor 2, cells survived but remained dormant and showed all the hallmarks of cellular senescence |
| 23666675 | X (ser139) localized to telomeres (chromatin immunoprecipitation; ChIP), and telomeric repeat binding factor 2 bound to telomeres (ChIP) was greater in arteries from older adults compared with those from younger adults |
| 15000677 | Decrease in TERF2 concentration (preventing t-loop formation) is accompanied by blockade of proliferation and appearance of other signs of cellular senescence in experiments |
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