HCSGD entry for TERF2


1. General information

Official gene symbolTERF2
Entrez ID7014
Gene full nametelomeric repeat binding factor 2
Other gene symbolsTRBF2 TRF2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000723Telomere maintenanceIMP TASbiological_process
GO:0000781Chromosome, telomeric regionIDAcellular_component
GO:0000783Nuclear telomere cap complexIDAcellular_component
GO:0001309Age-dependent telomere shorteningNASbiological_process
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003691Double-stranded telomeric DNA bindingISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0007004Telomere maintenance via telomeraseICbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0008022Protein C-terminus bindingIPImolecular_function
GO:0010834Telomere maintenance via telomere shorteningIMPbiological_process
GO:0016233Telomere cappingIMPbiological_process
GO:0030870Mre11 complexIDAcellular_component
GO:0031627Telomeric loop formationIDAbiological_process
GO:0031848Protection from non-homologous end joining at telomereIMPbiological_process
GO:0032205Negative regulation of telomere maintenanceIDAbiological_process
GO:0032214Negative regulation of telomere maintenance via semi-conservative replicationNASbiological_process
GO:0042162Telomeric DNA bindingIDA IEAmolecular_function
GO:0042803Protein homodimerization activityIEA IPImolecular_function
GO:0070198Protein localization to chromosome, telomeric regionIMPbiological_process
GO:0090398Cellular senescenceNASbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.22549439230.92618014130.90683699011.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0923195408
GSE13712_SHEARUp0.1753528435
GSE13712_STATICUp0.0457202206
GSE19018Down-0.0548010318
GSE19899_A1Up0.1350652943
GSE19899_A2Up0.7831775685
PubMed_21979375_A1Up0.7063390594
PubMed_21979375_A2Up0.4785409195
GSE35957Down-0.0292710303
GSE36640Down-0.0652715214
GSE54402Up0.3282946536
GSE9593Down-0.1569677731
GSE43922Up0.0380229708
GSE24585Up0.1185678700
GSE37065Up0.0107449571
GSE28863_A1Down-0.2485435980
GSE28863_A2Up0.0978930923
GSE28863_A3Down-0.0817298350
GSE28863_A4Up0.0692915579
GSE48662Down-0.2384233592

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT023208Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-26b-5pMIMAT0000083MIRT030265MicroarrayFunctional MTI (Weak)19088304
hsa-miR-766-3pMIMAT0003888MIRT039036CLASHFunctional MTI (Weak)23622248
hsa-miR-15b-5pMIMAT0000417MIRT046463CLASHFunctional MTI (Weak)23622248
hsa-miR-96-5pMIMAT0000095MIRT048736CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049699CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25840590When telomere dysfunction was induced in adult AEC2s by conditional deletion of the shelterin component telomeric repeat-binding factor 2, cells survived but remained dormant and showed all the hallmarks of cellular senescence
23666675X (ser139) localized to telomeres (chromatin immunoprecipitation; ChIP), and telomeric repeat binding factor 2 bound to telomeres (ChIP) was greater in arteries from older adults compared with those from younger adults
15000677Decrease in TERF2 concentration (preventing t-loop formation) is accompanied by blockade of proliferation and appearance of other signs of cellular senescence in experiments
Entries Per Page
Displaying Page of